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Clinical characteristics and outcomes of hematogenous vertebral osteomyelitis caused by gram-negative bacteria.

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dc.contributor.author석경수-
dc.date.accessioned2015-12-28T11:01:43Z-
dc.date.available2015-12-28T11:01:43Z-
dc.date.issued2014-
dc.identifier.issn0163-4453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138538-
dc.description.abstractOBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with hematogenous vertebral osteomyelitis (HVO) caused by gram-negative bacteria (GNB). METHODS: We conducted a retrospective chart review of adult patients with HVO from three tertiary-care hospitals over a 7-year period. RESULTS: Of the 313 microbiologically diagnosed HVO cases, GNB was responsible for 65 (20.8%) cases. Compared with patients with MSSA HVO, patients with GNB HVO were more likely to be female (P = 0.03) and have diabetes (P = 0.03), but less likely to have epidural abscess (P = 0.02) and paravertebral abscess (P = 0.003). Clinical outcomes were similar between the GNB and MSSA groups, including in-hospital mortality (4.6% vs. 7.8%; P = 0.53), recurrence (9.7% vs. 4.3%; P = 0.20), and sequelae (31.7% vs. 32.2%; P = 0.95). Among GNB-infected patients, recurrence rates differed according to the total duration of antibiotic treatment: 40.0% (4-6 weeks), 33.3% (6-8 weeks), and 2.1% (≥ 8 weeks) (P = 0.002). CONCLUSIONS: GNB HVO was responsible for 20.8% of adult cases of HVO. Despite some differences in clinical and radiological presentation, clinical outcomes were similar between GNB and MSSA HVO. Antibiotic therapy for ≥ 8 weeks may benefit patients with GNB HVO.-
dc.description.statementOfResponsibilityopen-
dc.format.extent42~50-
dc.relation.isPartOfJOURNAL OF INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHBacteremia/complications*-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHGram-Negative Bacterial Infections/drug therapy-
dc.subject.MESHGram-Negative Bacterial Infections/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteomyelitis/drug therapy-
dc.subject.MESHOsteomyelitis/pathology*-
dc.subject.MESHPrevalence-
dc.subject.MESHRecurrence-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSpondylitis/drug therapy-
dc.subject.MESHSpondylitis/pathology*-
dc.subject.MESHStaphylococcal Infections/drug therapy-
dc.subject.MESHStaphylococcal Infections/pathology-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTertiary Care Centers-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleClinical characteristics and outcomes of hematogenous vertebral osteomyelitis caused by gram-negative bacteria.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorKi Ho Park-
dc.contributor.googleauthorOh Hyun Cho-
dc.contributor.googleauthorMyounghwa Jung-
dc.contributor.googleauthorKyung Soo Suk-
dc.contributor.googleauthorJung Hee Lee-
dc.contributor.googleauthorJi Seon Park-
dc.contributor.googleauthorKyung Nam Ryu-
dc.contributor.googleauthorSung Han Kim-
dc.contributor.googleauthorSang Oh Lee-
dc.contributor.googleauthorSang Ho Choi-
dc.contributor.googleauthorIn Gyu Bae-
dc.contributor.googleauthorYang Soo Kim-
dc.contributor.googleauthorJun Hee Woo-
dc.contributor.googleauthorMi Suk Lee-
dc.identifier.doi10.1016/j.jinf.2014.02.009-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01926-
dc.relation.journalcodeJ01452-
dc.identifier.eissn1532-2742-
dc.identifier.pmid24561018-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0163445314000450-
dc.subject.keywordGram-negative bacteria-
dc.subject.keywordOutcome-
dc.subject.keywordSpondylitis-
dc.subject.keywordSpondylodiscitis-
dc.subject.keywordVertebral osteomyelitis-
dc.contributor.alternativeNameSuk, Kyung Soo-
dc.contributor.affiliatedAuthorSuk, Kyung Soo-
dc.rights.accessRightsfree-
dc.citation.volume69-
dc.citation.number1-
dc.citation.startPage42-
dc.citation.endPage50-
dc.identifier.bibliographicCitationJOURNAL OF INFECTION, Vol.69(1) : 42-50, 2014-
dc.identifier.rimsid38368-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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