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소아 급성백혈병에서 MLL 유전자의 부분일렬반복의 유병률과 임상적 의의
DC Field | Value | Language |
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dc.contributor.author | 김효선 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2015-12-28T11:00:29Z | - |
dc.date.available | 2015-12-28T11:00:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2233-5250 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138494 | - |
dc.description.abstract | Background: The mixed lineage leukemia (MLL) gene may induce hematopoiesis and leukemia. Partial tandem duplication of MLL (MLL-PTD) is associated with poor prog-nosis in acute myeloid leukemia (AML); however, the significance of MLL-PTD in acute lymphoblastic leukemia (ALL) has not been thoroughly studied. We evaluated the in-cidence, relationship with other cytogenetic abnormalities, and the prognostic role of MLL-PTD in ALL.Methods: We reviewed medical records from pediatric patients diagnosed with ALL in Severance Hospital, Yonsei University Health System, South Korea from 2002 to 2008. MLL-PTD was detected by nested reverse transcriptase polymerase chain reaction.Results: In ALL patients, 50.0% (42/84) were positive for MLL-PTD. There was no sig-nificant difference in the 10-year overall survival (10Y OS) and event-free survival (EFS) between MLL-PTD-positive (+) and MLL-PTD-negative (–) groups (69.4% vs. 76.2%, P=0.609, and 62.6% vs. 66.7%, P=0.818, respectively). The combination of high level of lactate dehydrogenase (>1,100 IU/L) and MLL-PTD(+) [MLL-PTD(+)/High LDH] was a statistically significant negative prognostic factor for 10Y OS and EFS (P=0.0226 and P=0.0230, respectively). In multivariate analysis, National Cancer Institute risk strat-ification and very high risk features were independent significant prognostic factors but MLL-PTD (+)/High LDH was not.Conclusion: MLL-PTD was observed frequently in pediatric ALL patients. MLL-PTD was not an independent prognostic factor. MLL-PTD (+)/High LDH should be evaluated fur-ther for its prognostic potential in ALL. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 71~79 | - |
dc.relation.isPartOf | Clinical Pediatric Hematology-Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 소아 급성백혈병에서 MLL 유전자의 부분일렬반복의 유병률과 임상적 의의 | - |
dc.title.alternative | Prevalence and Clinical Implication of Partial Tandem Duplication of the Mixed Lineage Leukemia Gene in Pediatric Acute Leukemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 진송이 | - |
dc.contributor.googleauthor | 한승민 | - |
dc.contributor.googleauthor | 김효선 | - |
dc.contributor.googleauthor | 유철주 | - |
dc.contributor.googleauthor | 한정우 | - |
dc.identifier.doi | 10.15264/cpho.2014.21.2.71 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A01201 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A04299 | - |
dc.relation.journalcode | J00605 | - |
dc.subject.keyword | Acute leukemia | - |
dc.subject.keyword | Cytogenetics | - |
dc.subject.keyword | Partial tandem duplication | - |
dc.subject.keyword | MLL | - |
dc.subject.keyword | Prognostic factors | - |
dc.subject.keyword | Pediatric leukemia | - |
dc.contributor.alternativeName | Kim, Hyo Sun | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Hahn, Seung Min | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Sun | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Hahn, Seung Min | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 71 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | Clinical Pediatric Hematology-Oncology, Vol.21(2) : 71-79, 2014 | - |
dc.identifier.rimsid | 45348 | - |
dc.type.rims | ART | - |
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