Cited 12 times in
Correlation between solid papillary carcinoma and associated invasive carcinoma according to expression of WT1 and several MUCs.
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2015-12-28T10:59:50Z | - |
dc.date.available | 2015-12-28T10:59:50Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138471 | - |
dc.description.abstract | OBJECTIVE: The aim of this study was to investigate the relationship between solid papillary carcinoma (SPC) and various subtypes of associated carcinomas, including mucinous carcinoma (MC) using several immunohistochemical staining. METHODS: We grouped cases according to the subtype of the associated invasive carcinoma and the presence of an extracellular mucin component. Immunohistochemical stains for WT1 and a series of MUCs were performed to determine the agreement of immunohistochemical expression between SPC and associated carcinomas. RESULTS: WT1 which is characteristically expressed in MC of breast showed high expression rate (22/46, 48%) in SPC. SPCs which are associated with MC or extracellular mucin showed higher rates of WT1 (10/12, 83%, p = 0.021) and MUC2 (8/12, 67%, p = 0.002) expression, compared to SPCs which were not associated with MC or extracellular mucin. SPC and the associated MC showed good agreement in WT1 (κ = 0.857, accuracy rate = 87.5%, 7/8) with a positive expression tendency. Meanwhile, SPC and the associated invasive carcinomas other than MC showed good agreement in WT1 (κ = 1.000, accuracy rate = 100%, 9/9) with a negative expression tendency and MUC1 (κ = 0.667, accuracy rate = 77.8%, 7/9). According to these results, we could speculate that SPC showing WT1 expression tends to progress to MC, and SPC lacking WT1 expression is more likely to progress to non-MC. CONCLUSION: SPCs can be a precursor lesion for MC and exhibit a potential to progress to other subtypes of invasive carcinoma. The status of WT1 expression in SPC could be a clue to know the direction of SPC progression, either MC or non-MC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 953~958 | - |
dc.relation.isPartOf | PATHOLOGY RESEARCH AND PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/metabolism* | - |
dc.subject.MESH | Adenocarcinoma, Mucinous/pathology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma, Papillary/metabolism* | - |
dc.subject.MESH | Carcinoma, Papillary/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mucins/metabolism* | - |
dc.subject.MESH | WT1 Proteins/metabolism* | - |
dc.title | Correlation between solid papillary carcinoma and associated invasive carcinoma according to expression of WT1 and several MUCs. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Eun Ji Oh | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.identifier.doi | 10.1016/j.prp.2014.06.026 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02474 | - |
dc.identifier.eissn | 1618-0631 | - |
dc.identifier.pmid | 25204785 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0344033814001964 | - |
dc.subject.keyword | Associated invasive carcinoma | - |
dc.subject.keyword | Precursor lesion | - |
dc.subject.keyword | Solid papillary carcinoma | - |
dc.subject.keyword | WT1 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 210 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 953 | - |
dc.citation.endPage | 958 | - |
dc.identifier.bibliographicCitation | PATHOLOGY RESEARCH AND PRACTICE, Vol.210(12) : 953-958, 2014 | - |
dc.identifier.rimsid | 45334 | - |
dc.type.rims | ART | - |
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