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Correlation between solid papillary carcinoma and associated invasive carcinoma according to expression of WT1 and several MUCs.

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dc.contributor.author구자승-
dc.contributor.author정우희-
dc.date.accessioned2015-12-28T10:59:50Z-
dc.date.available2015-12-28T10:59:50Z-
dc.date.issued2014-
dc.identifier.issn0344-0338-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138471-
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the relationship between solid papillary carcinoma (SPC) and various subtypes of associated carcinomas, including mucinous carcinoma (MC) using several immunohistochemical staining. METHODS: We grouped cases according to the subtype of the associated invasive carcinoma and the presence of an extracellular mucin component. Immunohistochemical stains for WT1 and a series of MUCs were performed to determine the agreement of immunohistochemical expression between SPC and associated carcinomas. RESULTS: WT1 which is characteristically expressed in MC of breast showed high expression rate (22/46, 48%) in SPC. SPCs which are associated with MC or extracellular mucin showed higher rates of WT1 (10/12, 83%, p = 0.021) and MUC2 (8/12, 67%, p = 0.002) expression, compared to SPCs which were not associated with MC or extracellular mucin. SPC and the associated MC showed good agreement in WT1 (κ = 0.857, accuracy rate = 87.5%, 7/8) with a positive expression tendency. Meanwhile, SPC and the associated invasive carcinomas other than MC showed good agreement in WT1 (κ = 1.000, accuracy rate = 100%, 9/9) with a negative expression tendency and MUC1 (κ = 0.667, accuracy rate = 77.8%, 7/9). According to these results, we could speculate that SPC showing WT1 expression tends to progress to MC, and SPC lacking WT1 expression is more likely to progress to non-MC. CONCLUSION: SPCs can be a precursor lesion for MC and exhibit a potential to progress to other subtypes of invasive carcinoma. The status of WT1 expression in SPC could be a clue to know the direction of SPC progression, either MC or non-MC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent953~958-
dc.relation.isPartOfPATHOLOGY RESEARCH AND PRACTICE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma, Mucinous/metabolism*-
dc.subject.MESHAdenocarcinoma, Mucinous/pathology-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCarcinoma, Papillary/metabolism*-
dc.subject.MESHCarcinoma, Papillary/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMucins/metabolism*-
dc.subject.MESHWT1 Proteins/metabolism*-
dc.titleCorrelation between solid papillary carcinoma and associated invasive carcinoma according to expression of WT1 and several MUCs.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorEun Ji Oh-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorJi Young Kim-
dc.contributor.googleauthorWoo Hee Jung-
dc.identifier.doi10.1016/j.prp.2014.06.026-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ02474-
dc.identifier.eissn1618-0631-
dc.identifier.pmid25204785-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0344033814001964-
dc.subject.keywordAssociated invasive carcinoma-
dc.subject.keywordPrecursor lesion-
dc.subject.keywordSolid papillary carcinoma-
dc.subject.keywordWT1-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsfree-
dc.citation.volume210-
dc.citation.number12-
dc.citation.startPage953-
dc.citation.endPage958-
dc.identifier.bibliographicCitationPATHOLOGY RESEARCH AND PRACTICE, Vol.210(12) : 953-958, 2014-
dc.identifier.rimsid45334-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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