Cited 46 times in
Hepatocellular Carcinomas Expressing ‘Stemness’-Related Markers:Clinicopathological Characteristics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2015-12-28T10:58:11Z | - |
dc.date.available | 2015-12-28T10:58:11Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0257-2753 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138413 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is heterogeneous in histopathology, pathogenesis and biological behavior. There is accumulating evidence that the expression of 'stemness'-related markers such as K19, EpCAM and CD133 in HCC is associated with an aggressive biological behavior and poor clinical outcome compared to conventional HCCs that do not express stemness-related markers. Compared to conventional HCCs, these tumors more frequently demonstrate infiltrative growth patterns, vascular invasion and more intratumoral fibrous stroma, and there is a spectrum of morphological and immunophenotypic features between HCCs with stemness-related marker expression, scirrhous HCCs and combined hepatocellular-cholangiocarcinoma with stem cell features. Clinically, HCCs with stemness-related marker expression are associated with increased serum α-fetoprotein levels and a poor prognosis, and are also beginning to be noticed radiologically. These tumors have also been recognized as a specific subtype in recent molecular classifications, and increasing interest in the molecular pathogenesis of HCCs with stemness-related marker expression will shed light on the development of targeted therapy for these tumors. Therefore, it is important that pathologists identify HCCs expressing stemness-related markers such as K19 during routine pathological evaluation of surgically resected or biopsied HCC tissue, as it will help to identify a high-risk subgroup of HCCs characterized by increased chemoresistance, earlier recurrence after surgical and/or locoregional treatment, increased invasiveness/metastasis and poor overall survival. We will discuss the clinicopathological characteristics of a HCC subtype expressing stemness-related markers and its future perspectives. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 778~785 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AC133 Antigen | - |
dc.subject.MESH | Antigens, CD/analysis | - |
dc.subject.MESH | Antigens, Neoplasm/analysis | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Biopsy, Needle | - |
dc.subject.MESH | Carcinoma, Hepatocellular/chemistry* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology* | - |
dc.subject.MESH | Cell Adhesion Molecules/analysis | - |
dc.subject.MESH | Epithelial Cell Adhesion Molecule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycoproteins/analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver Neoplasms/chemistry* | - |
dc.subject.MESH | Liver Neoplasms/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Invasiveness/pathology | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neoplastic Stem Cells/pathology* | - |
dc.subject.MESH | Peptides/analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | alpha-Fetoproteins/analysis | - |
dc.title | Hepatocellular Carcinomas Expressing ‘Stemness’-Related Markers:Clinicopathological Characteristics | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Haeryoung Kim | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.identifier.doi | 10.1159/000368021 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J00736 | - |
dc.identifier.eissn | 1421-9875 | - |
dc.identifier.pmid | 25376296 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/368021 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | K19 | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Stemness | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 778 | - |
dc.citation.endPage | 785 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES, Vol.32(6) : 778-785, 2014 | - |
dc.identifier.rimsid | 49161 | - |
dc.type.rims | ART | - |
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