Cited 197 times in
Smoking and rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2015-12-28T10:58:10Z | - |
dc.date.available | 2015-12-28T10:58:10Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138412 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by both genetic and environmental factors. Smoking has been implicated as one of the most important extrinsic risk factors for its development and severity. Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation and epigenetic changes. The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA. With increased use of biological agents in addition to standard disease-modifying antirheumatic drugs (DMARDs), there has been interest in how smoking affects drug response in RA treatment. Recent evidence suggests the response and drug survival in people treated with anti-tumour necrosis factor (anti-TNF) therapy is poorer in heavy smokers, and possible immunological mechanisms for this effect are presented in the current paper. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 22279~22295 | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Smoking and rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Kathleen Chang | - |
dc.contributor.googleauthor | So Min Yang | - |
dc.contributor.googleauthor | Seong Heon Kim | - |
dc.contributor.googleauthor | Kyoung Hee Han | - |
dc.contributor.googleauthor | Se Jin Park | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.identifier.doi | 10.3390/ijms151222279 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.subject.keyword | rheumatoid arthritis | - |
dc.subject.keyword | smoking | - |
dc.subject.keyword | cyclic citrullinated peptide | - |
dc.subject.keyword | synovial fibroblasts | - |
dc.subject.keyword | drug response | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.citation.volume | 15 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 22279 | - |
dc.citation.endPage | 22295 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.15(12) : 22279-22295, 2014 | - |
dc.identifier.rimsid | 49160 | - |
dc.type.rims | ART | - |
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