Cited 10 times in
Effects of cardiac medications for patients with obstructive coronary artery disease by coronary computed tomographic angiography: results from the multicenter CONFIRM registry
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2015-12-28T10:57:38Z | - |
dc.date.available | 2015-12-28T10:57:38Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138394 | - |
dc.description.abstract | OBJECTIVE: This study sought to determine the correlation between baseline cardiac medications and cardiovascular outcomes in patients with obstructive coronary artery disease (CAD) diagnosed by coronary computed tomographic angiography (CCTA). METHODS: 1637 patients (mean age 64.8 ± 10.2 years, 69.6% male) with obstructive CAD from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry were followed over the course of three years. Obstructive CAD was defined as a ≥50% stenosis in an epicardial vessel. Medications analyzed included statins, aspirin, beta-blockers, angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). Using Cox proportional-hazards models, we calculated the hazard ratio (HR) with 95% confidence intervals (95% CIs) for incident major adverse cardiovascular events (MACE), defined as death, acute coronary syndrome, or myocardial infarction. RESULTS: At the time of CCTA, 59%, 54%, 40%, and 46% of patients were using statins, aspirin, beta-blockers, and ACE inhibitors or ARBs, respectively. Statins were associated with a 43% (95% CI = 0.38-0.87, p = 0.008) lower adjusted risk of MACE. Following adjustment, aspirin, beta-blockers, ACE inhibitors and ARBs did not attenuate the risk of MACE. When restricted to patients with multivessel obstructive CAD, only statins were associated with lower risk of MACE. CONCLUSION: In patients with obstructive CAD by CCTA, the baseline use of statins was associated with improved clinical outcomes. Other cardiac medications-including aspirin, beta-blockers, ACE inhibitors, and ARBs-were not associated with reduced risk of MACE. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Algorithms | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Coronary Angiography* | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging* | - |
dc.subject.MESH | Coronary Artery Disease/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Tomography, X-Ray Computed* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effects of cardiac medications for patients with obstructive coronary artery disease by coronary computed tomographic angiography: results from the multicenter CONFIRM registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Joshua Schulman-Marcus | - |
dc.contributor.googleauthor | Bríain ó Hartaigh | - |
dc.contributor.googleauthor | Ashley E. Giambrone | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Valentina Valenti | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Matthew J. Budoff | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Mouaz Al-Mallah | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin J.W. Chow | - |
dc.contributor.googleauthor | Ricardo Cury | - |
dc.contributor.googleauthor | Augustin Delago | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Joerg Hausleiter | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Philipp A. Kaufmann | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | Fay Y. Lin | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Gilbert Raff | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | Allison Dunning | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2014.11.007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 25479800 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915014015706 | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Coronary computed tomographic angiography | - |
dc.subject.keyword | Major adverse cardiac events | - |
dc.subject.keyword | Medication therapy | - |
dc.subject.keyword | Statins | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 238 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 125 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.238(1) : 119-125, 2015 | - |
dc.identifier.rimsid | 49147 | - |
dc.type.rims | ART | - |
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