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DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis

 Shan Jin  ;  Chang Ook Park  ;  Jung U Shin  ;  Ji Yeon Noh  ;  Yun Sun Lee  ;  Na Ra Lee  ;  Hye Ran Kim  ;  Seongmin Noh  ;  Young Lee  ;  Jeung Hoon Lee  ;  Kwang Hoon Lee 
 EXPERIMENTAL DERMATOLOGY, Vol.23(12) : 938-941, 2014 
Journal Title
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Animals ; Calgranulin A/metabolism* ; Calgranulin B/metabolism* ; Cell Line ; Cytokines/metabolism ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/immunology* ; Dermatophagoides farinae/immunology* ; Dermatophagoides farinae/pathogenicity ; Humans ; Immunity, Innate ; Interleukin-17/metabolism* ; Interleukin-33 ; Interleukins/biosynthesis ; Interleukins/genetics ; Keratinocytes/immunology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Th17 Cells/immunology ; Th2 Cells/immunology ; Up-Regulation
Dermatophagoides farinae ; IL-17A ; IL-33 ; S100A8 ; S100A9 ; atopic dermatitis
S100A9 and S100A8 are called damage-associated molecular pattern (DAMP) molecules because of their pro-inflammatory properties. Few studies have evaluated S100A9 and S100A8 function as DAMP molecules in atopic dermatitis (AD). We investigated how house-dust mites affect S100A9 and S100A8 expression in Th2 cytokine- and Th17 cytokine-treated keratinocytes, and how secretion of these molecules affects keratinocyte-derived cytokines. Finally, we evaluated expression of these DAMP molecules in AD patients. S100A9 expression and S100A8 expression were strongly induced in IL-17A- and Dermatophagoides (D.) farinae-treated keratinocytes, respectively. Furthermore, co-treatment with D. farinae and IL-17A strongly increased expression of S100A9 and S100A8 compared with D. farinae-Th2 cytokine co-treatment. The IL-33 mRNA level increased in a dose-dependent manner in S100A9-treated keratinocytes, but TSLP expression did not change. S100A8/A9 levels were also higher in the lesional skin and serum of AD patients, and correlated with disease severity. Taken together, S100A9 and S100A8 may be involved in inducing DAMP-mediated inflammation in AD triggered by IL-17A and house-dust mites.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Jin, Shan(김산)
Kim, Hye Ran(김혜란)
Noh, Ji Yeon(노지연)
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Kwang Hoon(이광훈)
Lee, Na Ra(이나라)
Lee, Yun Sun(이윤선)
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