Cited 33 times in
Long-term outcomes of cytomegalovirus reactivation in patients with moderate to severe ulcerative colitis: a multicenter study.
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2015-12-28T10:57:09Z | - |
dc.date.available | 2015-12-28T10:57:09Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138377 | - |
dc.description.abstract | BACKGROUND/AIMS: Cytomegalovirus (CMV) reactivations are frequently observed in patients with active ulcerative colitis (UC), and ganciclovir therapy is effective in patients with steroid-refractory UC. This study aimed to determine the long-term outcomes of CMV reactivation and the long-term therapeutic efficacy of ganciclovir treatment. METHODS: This retrospective multicenter study included a cohort of 72 patients with moderate-to-severe UC who were evaluated for CMV reactivation at the time of their initial UC flare. Colectomy, disease relapse, and the recurrence rate of CMV reactivation were investigated. RESULTS: The mean duration of follow-up for the 72 patients was 43.16±19.78 months (range, 1 to 67 months). The cumulative colectomy (log-rank, p=0.025) and disease flare-up rates (log-rank, p=0.048) were significantly higher in the CMV-positive group. Of the 11 patients who were successfully treated with ganciclovir in the initial treatment, three patients (27.3%) experienced CMV reactivation, and six patients (54.5%) experienced poor outcomes, such as the need for colectomy or a steroid-dependent state. CONCLUSIONS: The patients who had CMV-reactivated UC showed poor outcomes at the long-term follow-up, and the long-term efficacy of ganciclovir therapy was marginal. Careful assessment is necessary for patients who exhibit evidence of CMV reactivation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 643~647 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antiviral Agents/therapeutic use* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Colectomy/utilization | - |
dc.subject.MESH | Colitis, Ulcerative/complications | - |
dc.subject.MESH | Colitis, Ulcerative/drug therapy* | - |
dc.subject.MESH | Cytomegalovirus* | - |
dc.subject.MESH | Cytomegalovirus Infections/complications | - |
dc.subject.MESH | Cytomegalovirus Infections/drug therapy* | - |
dc.subject.MESH | Ganciclovir/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Virus Activation* | - |
dc.title | Long-term outcomes of cytomegalovirus reactivation in patients with moderate to severe ulcerative colitis: a multicenter study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | You Sun Kim | - |
dc.contributor.googleauthor | Young Ho Kim | - |
dc.contributor.googleauthor | Joo Sung Kim | - |
dc.contributor.googleauthor | Seong Yeon Jeong | - |
dc.contributor.googleauthor | Soo Jeong Park | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Byong Duk Ye | - |
dc.contributor.googleauthor | Sung Ae Jung | - |
dc.contributor.googleauthor | Young Sook Park | - |
dc.contributor.googleauthor | Chang Hwan Choi | - |
dc.contributor.googleauthor | Kyeung Ok Kim | - |
dc.contributor.googleauthor | Byung Ik Jang | - |
dc.contributor.googleauthor | Dong Soo Han | - |
dc.contributor.googleauthor | Suk Kyun Yang | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.5009/gnl13427 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01539 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 25368753 | - |
dc.subject.keyword | Colitis | - |
dc.subject.keyword | ulcerative | - |
dc.subject.keyword | Cytomegalovirus | - |
dc.subject.keyword | Ganciclovir | - |
dc.subject.keyword | Colectomy | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 643 | - |
dc.citation.endPage | 647 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.8(6) : 643-647, 2014 | - |
dc.identifier.rimsid | 49136 | - |
dc.type.rims | ART | - |
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