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At least one cyclic teriparatide administration can be helpful to delay initial onset of a new osteoporotic vertebral compression fracture

DC FieldValueLanguage
dc.contributor.author김학선-
dc.contributor.author문성환-
dc.contributor.author박진오-
dc.contributor.author석경수-
dc.contributor.author이환모-
dc.date.accessioned2015-12-28T10:57:04Z-
dc.date.available2015-12-28T10:57:04Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138374-
dc.description.abstractPURPOSE: Teriparatide markedly increases bone formation and strength, while reducing the incidence of new-onset osteoporotic vertebral compression fractures (OVCFs). In some countries, expenses for teriparatide use are covered by medical insurance for up to 6 months; however, the national medical insurance of the authors' country does not cover these expenses. This retrospective cohort study compared the therapeutic effects of teriparatide on the initial onset of a new OVCF after treatment of osteoporosis and/or related OVCFs with regard to therapeutic durations of longer than 3 months (LT3M) or shorter than 3 months (ST3M). MATERIALS AND METHODS: From May 2007 to February 2012, 404 patients who were prescribed and administered teriparatide and who could be followed-up for longer than 12 months were enrolled. They were divided into two groups depending on teriparatide duration: LT3M (n=132) and ST3M (n=272). RESULTS: The group with the teriparatide duration of LT3M showed significantly less development of an initial OVCF within 1 year (p=0.004, chi-square). Duration of teriparatide use, body mass index, pre-teriparatide lowest spinal bone mineral density, and severity of osteoporosis significantly affected multiple regression analysis results (p<0.05). Survival analysis of first new-onset OVCFs demonstrated a significantly better survival rate for the LT3M group (log rank, p=0.005). Also, the ST3M group showed a higher odds ratio of 54.00 for development of an initial OVCF during follow-up than the LT3M group (Mantel-Haenzel common odds ratio, p=0.006). CONCLUSION: At least one cyclic teriparatide administration is recommended to provide a protective effect against the initial onset of a new OVCF for up to one year after therapy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1576~1583-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAt least one cyclic teriparatide administration can be helpful to delay initial onset of a new osteoporotic vertebral compression fracture-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorKyung Soo Suk-
dc.contributor.googleauthorHwan Mo Lee-
dc.contributor.googleauthorSeong Hwan Moon-
dc.contributor.googleauthorHee June Kim-
dc.contributor.googleauthorHak Sun Kim-
dc.contributor.googleauthorJin Oh Park-
dc.contributor.googleauthorByung Ho Lee-
dc.identifier.doi10.3349/ymj.2014.55.6.1576-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01093-
dc.contributor.localIdA01365-
dc.contributor.localIdA01703-
dc.contributor.localIdA01926-
dc.contributor.localIdA03333-
dc.relation.journalcodeJ02813-
dc.contributor.alternativeNameKim, Hak Sun-
dc.contributor.alternativeNameMoon, Seong Hwan-
dc.contributor.alternativeNamePark, Jin Oh-
dc.contributor.alternativeNameSuk, Kyung Soo-
dc.contributor.alternativeNameLee, Hwan Mo-
dc.contributor.affiliatedAuthorKim, Hak Sun-
dc.contributor.affiliatedAuthorMoon, Seong Hwan-
dc.contributor.affiliatedAuthorPark, Jin Oh-
dc.contributor.affiliatedAuthorSuk, Kyung Soo-
dc.contributor.affiliatedAuthorLee, Hwan Mo-
dc.citation.volume55-
dc.citation.number6-
dc.citation.startPage1576-
dc.citation.endPage1583-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.55(6) : 1576-1583, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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