Cited 16 times in
The role of radiotherapy in the management of POEMS syndrome.
DC Field | Value | Language |
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dc.contributor.author | 김유리 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 서양권 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 조재호 | - |
dc.date.accessioned | 2015-12-28T10:54:24Z | - |
dc.date.available | 2015-12-28T10:54:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138279 | - |
dc.description.abstract | BACKGROUND: POEMS syndrome is a paraneoplastic syndrome caused by an underlying plasma cell proliferative disease. In this study, we examined the treatment outcomes and role of radiotherapy in the management of POEMS syndrome. METHODS: In total, 33 patients diagnosed with POEMS syndrome were analyzed. These patients presented with osteosclerotic myeloma (OSM, n = 13), Castleman's disease (CD, n = 4), OSM with CD (n = 10), and vascular endothelial growth factor elevation without gross lesions (VEGFe, n = 6), respectively. The patients were treated by radiotherapy alone (n = 4), chemotherapy alone (n = 16), or a combination thereof (n = 9). RESULTS: The clinical response rates of radiotherapy, chemotherapy, and radiotherapy plus chemotherapy were 75%, 69%, and 89%, respectively. In addition, the hematologic response rates were 50%, 69%, and 71%, respectively. Among the six patients with limited multiple lesions who underwent radiotherapy, the clinical symptoms were improved in five patients after radiotherapy. The median progression-free survival (PFS) was 51 months, and the median overall survival (OS) was 65 months. In univariate analysis, the administration of chemotherapy was significantly associated with better PFS (p = 0.007) and OS (p = 0.020). In contrast, underlying VEGFe was a significant factor worsening PFS (p = 0.035) and OS (p = 0.008). CONCLUSIONS: Radiotherapy produces a reliable clinical response and is effective in improving POEMS-associated symptoms that are refractory to chemotherapy in selected patients with clustered or limited multiple lesions that can be covered by single radiation field. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 265 | - |
dc.relation.isPartOf | RADIATION ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | POEMS Syndrome/mortality | - |
dc.subject.MESH | POEMS Syndrome/radiotherapy* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | The role of radiotherapy in the management of POEMS syndrome. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yang Gun Suh | - |
dc.contributor.googleauthor | Young Suk Kim | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.contributor.googleauthor | Yu Ri Kim | - |
dc.contributor.googleauthor | June Won Cheong | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.identifier.doi | 10.1186/s13014-014-0265-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01891 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A00779 | - |
dc.relation.journalcode | J02591 | - |
dc.identifier.eissn | 1748-717X | - |
dc.identifier.pmid | 25431020 | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Osteosclerotic myeloma | - |
dc.subject.keyword | Castleman’s disease | - |
dc.subject.keyword | Monoclonal gammopathy | - |
dc.subject.keyword | Polyneuropathy | - |
dc.contributor.alternativeName | Kim, Yu Ri | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Suh, Yang Gun | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Suh, Yang Gun | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Kim, Yu Ri | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 265 | - |
dc.identifier.bibliographicCitation | RADIATION ONCOLOGY, Vol.9 : 265, 2014 | - |
dc.identifier.rimsid | 52774 | - |
dc.type.rims | ART | - |
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