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Long-acting anticholinergic agents in patients with uncontrolled asthma: A systematic review and meta-analysis

DC Field Value Language
dc.contributor.author변민광-
dc.contributor.author정지예-
dc.date.accessioned2015-12-28T10:54:08Z-
dc.date.available2015-12-28T10:54:08Z-
dc.date.issued2014-
dc.identifier.issn1027-3719-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138269-
dc.description.abstractSETTING: A novel effective treatment is necessary for severe asthma. OBJECTIVE: To review clinical trials examining the role of tiotropium in patients with poorly controlled asthma despite inhaled corticosteroid use with or without long-acting β₂-agonists. DESIGN: A computerised search of electronic databases (Medline, EMBASE and Cochrane Central Register) was performed. Randomised controlled trials of at least a 4-week treatment duration with findings published in English were included. RESULTS: Five studies involving 1635 patients were analysed. Compared with a placebo or a double dose of inhaled corticosteroids, the addition of tiotropium increased mean trough and peak forced expiratory volume in 1 second by 97 ml (95%CI 71-122) and 103 ml (95%CI 42-163), respectively. The mean differences in morning peak expiratory flow were 19.2 l/min (95%CI 11.8-26.6). Tiotropium also reduced the risk of severe acute exacerbation (OR 0.73, 95%CI 0.56-0.96) and improved Asthma Quality-of-Life Questionnaire score significantly by 0.10 (95%CI 0.04-0.16). There were no differences in serious adverse events. CONCLUSION: The addition of tiotropium may be beneficial for patients with poorly controlled asthma, although exacerbation or safety issues should be clarified in long-term trials before its wide use in asthma.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1421~1430-
dc.languageEnglish-
dc.publisherThe Union-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnti-Asthmatic Agents/adverse effects-
dc.subject.MESHAnti-Asthmatic Agents/therapeutic use*-
dc.subject.MESHAsthma/diagnosis-
dc.subject.MESHAsthma/drug therapy*-
dc.subject.MESHAsthma/physiopathology-
dc.subject.MESHBronchodilator Agents/adverse effects-
dc.subject.MESHBronchodilator Agents/therapeutic use*-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCholinergic Antagonists/adverse effects-
dc.subject.MESHCholinergic Antagonists/therapeutic use*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHLung/drug effects*-
dc.subject.MESHLung/physiopathology-
dc.subject.MESHOdds Ratio-
dc.subject.MESHQuality of Life-
dc.subject.MESHRandomized Controlled Trials as Topic-
dc.subject.MESHScopolamine Derivatives/adverse effects-
dc.subject.MESHScopolamine Derivatives/therapeutic use*-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTiotropium Bromide-
dc.subject.MESHTreatment Outcome-
dc.titleLong-acting anticholinergic agents in patients with uncontrolled asthma: A systematic review and meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorS W Lee-
dc.contributor.googleauthorH J Kim-
dc.contributor.googleauthorK H Yoo-
dc.contributor.googleauthorY B Park-
dc.contributor.googleauthorJ Y Park-
dc.contributor.googleauthorJ Y Jung-
dc.contributor.googleauthorJ Y Moon-
dc.contributor.googleauthorM K Byun-
dc.contributor.googleauthorS W Kim-
dc.contributor.googleauthorY H Kim-
dc.identifier.doi10.5588/ijtld.14.0275-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01848-
dc.contributor.localIdA03735-
dc.relation.journalcodeJ01167-
dc.identifier.eissn1815-7920-
dc.identifier.pmid25517806-
dc.identifier.urlhttp://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000012/art00008-
dc.subject.keywordasthma-
dc.subject.keywordtiotropium-
dc.subject.keywordanticholinergics-
dc.contributor.alternativeNameByun, Min Kwang-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.affiliatedAuthorByun, Min Kwang-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.rights.accessRightsfree-
dc.citation.volume18-
dc.citation.number12-
dc.citation.startPage1421-
dc.citation.endPage1430-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.18(12) : 1421-1430, 2014-
dc.identifier.rimsid52767-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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