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Human telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas
DC Field | Value | Language |
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dc.contributor.author | 김은경 | - |
dc.contributor.author | 김진 | - |
dc.contributor.author | 문숙 | - |
dc.contributor.author | 박영진 | - |
dc.contributor.author | 배정윤 | - |
dc.contributor.author | 홍두표 | - |
dc.date.accessioned | 2015-12-28T10:52:51Z | - |
dc.date.available | 2015-12-28T10:52:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138225 | - |
dc.description.abstract | BACKGROUND/AIM: The present study aimed to investigate whether the down-regulation of human telomerase reverse transcriptase (hTERT) may induce an anti-invasive effect in oral squamous cell cancer cell lines. MATERIALS AND METHODS: A genetically-engineered squamous carcinoma cell line overexpressing hTERT in immortalized oral keratinocytes transfected by human papilloma virus (HPV)-16 E6/E7 (IHOK) was used. In vivo tumorigenicity was examined using an orthotopic xenograft model of nude mice. For evaluating anti-invasive activity by knockdown of hTERT expression, transwell invasion assay and real-time polymerase chain reaction (PCR) for matrix metalloproteinases (MMP) were employed. RESULTS: The down-regulation of hTERT expression reduced the invasive activity and MMP expression. This result was re-confirmed in the HSC3 oral squamous carcinoma cell line. CONCLUSION: Targeting hTERT may lead to novel therapeutic approaches. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Human telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Oral Cancer Research Institute (구강종양연구소) | - |
dc.contributor.googleauthor | YOUNG-JIN PARK | - |
dc.contributor.googleauthor | EUN-KYOUNG KIM | - |
dc.contributor.googleauthor | SOOK MOON | - |
dc.contributor.googleauthor | DOO-PYO HONG | - |
dc.contributor.googleauthor | JUNG YOON BAE | - |
dc.contributor.googleauthor | JIN KIM | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00800 | - |
dc.contributor.localId | A04390 | - |
dc.contributor.localId | A01009 | - |
dc.contributor.localId | A01571-1 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 25368238 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/34/11/6389.long | - |
dc.subject.keyword | Human telomerase reverse transcriptase (hTERT) | - |
dc.subject.keyword | immortal oral keratinocytes | - |
dc.subject.keyword | multi-step process | - |
dc.subject.keyword | squamous cell carcinoma | - |
dc.contributor.alternativeName | Kim, Eun Kyoung | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Moon, Sook | - |
dc.contributor.alternativeName | Park, Young Jin | - |
dc.contributor.alternativeName | Bae, Jung Yoon | - |
dc.contributor.alternativeName | Hong, Doo Pyo | - |
dc.contributor.affiliatedAuthor | Kim, Eun Kyoung | - |
dc.contributor.affiliatedAuthor | Hong, Doo Pyo | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.contributor.affiliatedAuthor | Park, Young Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6389 | - |
dc.citation.endPage | 6395 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.34(11) : 6389-6395, 2014 | - |
dc.identifier.rimsid | 47235 | - |
dc.type.rims | ART | - |
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