0 511

Cited 0 times in

Human telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas

DC Field Value Language
dc.contributor.author김은경-
dc.contributor.author김진-
dc.contributor.author문숙-
dc.contributor.author박영진-
dc.contributor.author배정윤-
dc.contributor.author홍두표-
dc.contributor.author배정윤-
dc.date.accessioned2015-12-28T10:52:51Z-
dc.date.available2015-12-28T10:52:51Z-
dc.date.issued2014-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138225-
dc.description.abstractBACKGROUND/AIM: The present study aimed to investigate whether the down-regulation of human telomerase reverse transcriptase (hTERT) may induce an anti-invasive effect in oral squamous cell cancer cell lines. MATERIALS AND METHODS: A genetically-engineered squamous carcinoma cell line overexpressing hTERT in immortalized oral keratinocytes transfected by human papilloma virus (HPV)-16 E6/E7 (IHOK) was used. In vivo tumorigenicity was examined using an orthotopic xenograft model of nude mice. For evaluating anti-invasive activity by knockdown of hTERT expression, transwell invasion assay and real-time polymerase chain reaction (PCR) for matrix metalloproteinases (MMP) were employed. RESULTS: The down-regulation of hTERT expression reduced the invasive activity and MMP expression. This result was re-confirmed in the HSC3 oral squamous carcinoma cell line. CONCLUSION: Targeting hTERT may lead to novel therapeutic approaches.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHuman telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorYOUNG-JIN PARK-
dc.contributor.googleauthorEUN-KYOUNG KIM-
dc.contributor.googleauthorSOOK MOON-
dc.contributor.googleauthorDOO-PYO HONG-
dc.contributor.googleauthorJUNG YOON BAE-
dc.contributor.googleauthorJIN KIM-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00800-
dc.contributor.localIdA04390-
dc.contributor.localIdA01009-
dc.contributor.localIdA01571-1-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid25368238-
dc.identifier.urlhttp://ar.iiarjournals.org/content/34/11/6389.long-
dc.subject.keywordHuman telomerase reverse transcriptase (hTERT)-
dc.subject.keywordimmortal oral keratinocytes-
dc.subject.keywordmulti-step process-
dc.subject.keywordsquamous cell carcinoma-
dc.contributor.alternativeNameKim, Eun Kyoung-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameMoon, Sook-
dc.contributor.alternativeNamePark, Young Jin-
dc.contributor.alternativeNameBae, Jung Yoon-
dc.contributor.alternativeNameHong, Doo Pyo-
dc.contributor.affiliatedAuthorKim, Eun Kyoung-
dc.contributor.affiliatedAuthorHong, Doo Pyo-
dc.contributor.affiliatedAuthorKim, Jin-
dc.contributor.affiliatedAuthorPark, Young Jin-
dc.rights.accessRightsfree-
dc.citation.volume34-
dc.citation.number11-
dc.citation.startPage6389-
dc.citation.endPage6395-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.34(11) : 6389-6395, 2014-
dc.identifier.rimsid47235-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.