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PPAR gamma agonist reduces amyloid pathology in aged senescence mice model : mechanisms involving LRP1 expression
DC Field | Value | Language |
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dc.contributor.author | 석한나 | - |
dc.date.accessioned | 2015-12-24T09:48:15Z | - |
dc.date.available | 2015-12-24T09:48:15Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/136605 | - |
dc.description | Dept. of Medicine/박사 | - |
dc.description.abstract | Objective. The role of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in Alzheimer’s disease (AD) is still controversial. Low-density lipoprotein receptor-related protein 1 (LRP1) is known to play an important role in secretion of amyloid-β (Aβ) in AD. The current study is carried out to investigate the effect of pioglitazone, PPAR-γ agonist, on Aβ deposition, LRP1 expression, and memory impairment in a senescence mouse model.Methods. Pioglitazone was orally administrated to 9-month-old SAMP8 mice in variable doses (0.5 mg/kg/day, 2 mg/kg/day and 5 mg/kg/day) for 7 weeks. Memory function was assessed using Morris water maze test. Aβ deposition and LRP1 expression in mice brain were investigated.Results. Pioglitazone treatment showed improvement in memory impairment. Pioglitazone-treated SAMP8 mice showed reduced Aβ deposition than vehicle-treated mice. In addition, increased LRP1 expression in microvessel was observed in pioglitazone-treated SAMP8 mice.Conclusion. These results suggest that pioglitazone may provide a protective effect against memory impairment through increasing LRP1 expression in blood-brain barrier and reducing Aβ deposition. Pioglitazone could have a therapeutic potential for the treatment of AD. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | PPAR gamma agonist reduces amyloid pathology in aged senescence mice model : mechanisms involving LRP1 expression | - |
dc.title.alternative | PPAR gamma 작용제가 고령의 노화동물 모델에서 LRPI의 발현 및 amyloid beta 단백의 침적에 미치는 영향 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.localId | A01930 | - |
dc.contributor.alternativeName | Seok, Hannah | - |
dc.contributor.affiliatedAuthor | 석한나 | - |
dc.type.local | Dissertation | - |
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