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Plasma metabolic profiling in male patients with newly-diagnosed type 2 diabetes : association with inflammatory and oxidative stress markers and arterial stiffness
DC Field | Value | Language |
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dc.contributor.author | 하창영 | - |
dc.date.accessioned | 2015-12-24T09:43:10Z | - |
dc.date.available | 2015-12-24T09:43:10Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/136401 | - |
dc.description | Graduate Program in Science for Aging/박사 | - |
dc.description.abstract | This study investigated whether circulating metabolic intermediates are associated with inflammation, oxidative stress, and arterial stiffness in newly-diagnosed type 2 diabetes men. newly-diagnosed type 2 diabetes men (n=26) and age- and body mass index-matched healthy men (n=27) were included. We measured inflammatory and oxidative markers and arterial stiffness by brachial-ankle pulse wave velocity (ba-PWV). Metabolomic profiling was analyzed with UPLC/Q-TOF MS. Diabetes patients showed higher levels of glucose, triglyceride, oxidized-LDL, hs C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), homeostasis model assessment-insulin resistance, urinary 8-epi-prostaglandin F2α (8-epi-PGF2α), and ba-PWV than healthy men. In plasma, 19 metabolites including leucine, lysine and phenylalanine , 8 acylcarnitines, 6 lyso-phosphatidylcholines (lysoPCs) and 2 lyso-phosphatidylethanolamines (lysoPEs) significantly increased in diabetes patients, whereas serine and lysoPE (C18:1) decreased. Decanoyl carnitine, lysoPCs (C14:0, C16:1, C18:1, and C22:6), and lysoPE (C18:1) were major plasma metabolites that distinguished healthy and diabetic men. Decanoyl carnitine positively correlated with oxidized-LDL, 8-epi-PGF2α, IL-6, and TNF-α, and ba-PWV. Ba-PWV correlated positively with lysoPCs C14:0 and C16:1, and negatively with lysoPE C18:1. 8-epi-PGF2α correlated positively with lipoprotein-associated phospholipaseA2, ba-PWV and lysoPCs (C14:0 and C16:1). Metabolic analysis revealed that circulating intermediate metabolites are closely associated with inflammation, oxidative stress, and arterial stiffness in early diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Plasma metabolic profiling in male patients with newly-diagnosed type 2 diabetes : association with inflammatory and oxidative stress markers and arterial stiffness | - |
dc.title.alternative | 염증성 지표 및 산화 스트레스와 동맥경화도의 관계 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Ha, Chang Young | - |
dc.type.local | Dissertation | - |
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