Evaluation of an improved technique for pulmonary function using impedance pulmonary function measurement system and average airway resistivity model : the diagnosis of chronic obstructive pulmonary disease patients

Abstract

Abbreviations

List of Figures

List of Tables

Abstract in English

Chapter 1 Introduction

1.1 Research motivation

1.2 Research hypotheses

1.3 Objectives of current study

Chapter 2 Review of literature

2.1 Overview

2.2 Respiration measurement

2.2.1 Physiological meaning of pulmonary mechanics

2.2.2 Methods for respiration measurement

2.3 Respiratory plethysmography

2.3.1 Tissue impedance

2.3.2 Electrical impedance plethysmography

2.3.3 Respiratory inductive plethysmography

2.4 Previous models for lung ventilation

2.4.1 Alveolus model

2.4.2 Lung compliance and flow resistance

2.5 Insufficiency of existing researches about respiratory plethysmography

Chapter 3 Method

3.1 Overview

3.2 Development system for impedance pulmonary function measurement system

(IPFS)

3.2.1 System configuration

3.2.2 Improvement in resolution of IPFS

3.2.3 Signal processing of IPFS

3.2.4 Measurement of IPFS using hand-held typed electrode

3.3 Development of average airway resistivity model

3.4 The reproducibility of developed IPFS

3.5 The subjects for clinical trials

3.6 The clinical trial procedures

3.6.1 Investigation of effects of subjects’ postures during IPFS measurements

3.6.2 Agreement between natural breaths and forced expiration for the PFT module

and the IPFS

3.6.3 Comparison of PFT indices obtained by spirometry with those obtained by the

IPFS

3.7 Statistical analysis

Chapter 4 Results

4.1 Overview

4.2 Measurement results by Postures

4.3 Agreement between volume and flow signals for PFT and IPFS

4.4 Classification between normal and COPD patient group

4.4.1 Result of PEF between spirometry and IPFS

4.4.2 Result of FVC between spirometry and IPFS

4.4.3 Result of FEV1 between spirometry and IPFS

4.4.4 Result of FEV1/FVC between spirometry and IPFS

4.5 The average airway resistivity model result

Chapter 5 Discussion

Chapter 6 Conclusions

References

Abstract in Korean

Appendix 1 IRB Approved

Appendix 2 Explanation

Appendix 3 Consent

Appendix 4 Research Papers

Appendix 5 Patents