Cited 0 times in
Serial optical coherence tomographic observation of neointimal tissue after bare-metal and everolimus-eluting stent in porcine coronary artery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 원호연 | - |
dc.date.accessioned | 2015-12-24T09:07:27Z | - |
dc.date.available | 2015-12-24T09:07:27Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/135011 | - |
dc.description | Dept. of Medicine/박사 | - |
dc.description.abstract | Objectives: To evaluate serial changes in neointimal tissues between everolimus-eluting stent (EES) and bare-metal stent (BMS) in normal porcine coronary artery using optical coherence tomography (OCT). Background: Serial changes in neointimal tissue after drug-eluting stent implantation have not been sufficiently investigated using OCT. Methods: Serial (1, 3 and 6 months follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in normal porcine coronary arteries. Qualitative and quantitative changes of neointimal tissues in stented segments with maximal percentage of cross-sectional area stenosis of neointima at 1 month follow-up were serially evaluated. Results: In BMS-implanted lesions, neointimal volume did not significantly change from median 6.5 (interquartile (IQR) 4.7-7.6) mm3 to 6.9 (IQR 4.6-8.2) mm3, 6.4 (IQR 4.3-7.4) mm3 at 1, 3 and 6 months follow-up (p=0.882). At different time point of 1, 3 ant 6 months, neointimal tissue appearance was mainly the homogeneous pattern (80.0%, 93.3% and 100%, respectively), while the layered pattern decreased (20.0%, 6.7% and 0%, respectively). On the other hands, in EES-implanted lesions, neointimal volume increased median 4.8 (IQR 4.1-7.6) mm3 to 9.8 (IQR 5.7-15.1) mm3 between 1 and 3 months (p<0.001), but significantly decreased to 8.6 (IQR 6.0-11.2) mm3 between 3 and 6 months (p=0.007). Between 1 and 3 months, the layered pattern of neointima increased from 26.7% to 66.7%, but deceased to 20.0% between 3 and 6 months. Conclusion: In this animal model, this OCT study showed that EES had a biphasic pattern of neointimal amounts which was correlated with change of neointimal morphology. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serial optical coherence tomographic observation of neointimal tissue after bare-metal and everolimus-eluting stent in porcine coronary artery | - |
dc.title.alternative | 돼지 관상동맥에 일반 금속 스텐트와 에버롤리무스 용출 스텐트를 삽입 한 후 혈관내 광단층영상을 이용한 신생내막의 연속적인 변화 관찰 연구 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.localId | A02448 | - |
dc.contributor.alternativeName | Won, Hoyoun | - |
dc.contributor.affiliatedAuthor | 원호연 | - |
dc.type.local | Dissertation | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.