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Sex differences in remifentanil requirements for preventing cough during anesthetic emergence

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dc.descriptionDept. of Medicine/석사-
dc.description.abstractPurpose: Target-controlled infusion (TCI) of remifentanil can suppress coughing during emergence from general anesthesia, but previous studies under different clinical conditions have recommended significantly different effective effect-site concentrations (effective Ce) of remifentanil for 50% of patients (EC50). The differences among these studies include type of surgery and patient sex. In recent years, there has been a growing interest in studying sex differences in anesthetic pharmacology. Therefore, we determined the effective Ce of remifentanil for each sex under the same clinical conditions. Materials and Methods: Twenty female and twenty-five male ASA I–II grade patients between the ages of 20 and 46 who were undergoing thyroidectomy were enrolled in this study. The effective Ce of remifentanil for preventing cough was determined for each sex using the isotonic regression method with a bootstrapping approach following Dixon’s up-and-down method. Results: Isotonic regression with a bootstrapping approach showed that the estimated EC50 of remifentanil for preventing coughing during emergence was significantly lower in females [1.30 ng/ml (83% confidence interval, 1.20–1.47 ng/ml)] than in males [2.57 ng/ml (83% CI, 2.45–2.70 ng/ml)]. Mean EC50 in females was also significantly lower than in males (1.23 ± 0.21 ng/ml vs. 2.43 ± 0.21 ng/ml, P<0.001). MAP, HR and RR over time were not significantly different between the sexes. Conclusion: When using remifentanil TCI for cough prevention during anesthetic emergence, patient sex should be a considered for appropriate dosing.-
dc.publisherGraduate School, Yonsei University-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSex differences in remifentanil requirements for preventing cough during anesthetic emergence-
dc.title.alternative마취회복 중 발생하는 기침을 적절히 억제하기 위한 레미펜타닐 효과처 농도의 성별간 차이-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.alternativeNameSoh, Sa Rah-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 2. Thesis


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