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Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid carcinoma
DC Field | Value | Language |
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dc.contributor.author | 홍진우 | - |
dc.date.accessioned | 2015-12-24T08:45:11Z | - |
dc.date.available | 2015-12-24T08:45:11Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/134143 | - |
dc.description | Dept. of Medical Science/박사 | - |
dc.description.abstract | Akt-dependent FOXO3a cytoplasmic translocation is an important tumorigenic mechanism for escaping from apoptosis in cancer cells. In the present study, we examined whether non-phosphorylatable FOXO3a can inhibit cell growth of distinct follicular thyroid carcinoma(FTC) cell lines. Adenovirus carrying the FOXO3a-triple mutant (TM) sequence including point mutations at three Akt phosphorylation sites (Ad-FOXO3a-TM) was generated and transduced to the cells to mimic inhibition of Akt/FOXO3a signal. Transduction of Ad-FOXO3a-TM to FTC cells induced cell cycle arrest and apoptosis. Intratumor injection of Ad-FOXO3a-TM suppressed the growth of xenograft tumors induced in athymic mice by FTC133 cells. Consequently, our results indicate that gene therapy based on Ad-FOXO3a-TM resulting in constitutively activated FOXO3a signaling has therapeutic potential for FTC. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid carcinoma | - |
dc.title.alternative | 지속적으로 활성화된 FOXO3로 Akt/FOXO3a 신호 전달 억제시 유도되는 갑상선 난포암 성장 억제 효과 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Hong, Zhen Yu | - |
dc.type.local | Dissertation | - |
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