Influences of triggering receptor expressed on myeloid cells-1 genetic polymorphisms on genotypes and phenotypes in Korean patients with inflammatory bowel diseases

Abstract

[한글]

[영문]Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). We hypothesized that TREM-1 genetic polymorphisms might be associated with IBD development and its phenotypes. We genotyped three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) and evaluated the relationships between these SNPs and IBD genotypes and phenotypes. We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet’s disease, and in particular with skin involvement and risk of azathioprine use. However, TREM-1 SNPs were not significantly associated with the development of Crohn’s disease or ulcerative colitis. The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet’s disease and may have modest effects on disease severity.