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The effects of deep brain stimulation in neuropathic pain induced rats
DC Field | Value | Language |
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dc.contributor.author | 김재형 | - |
dc.date.accessioned | 2015-11-21T07:50:23Z | - |
dc.date.available | 2015-11-21T07:50:23Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/125246 | - |
dc.description | Dept. of Medical Science/박사 | - |
dc.description.abstract | Neuropathic pain induced by peripheral nerve injury is clinically very common. High-frequency deep brain stimulation (DBS) is an effective treatment for chronic neuropathic pain, but the mechanisms underlying its analgesic effects are not precisely known. I investigated the mechanism of high-frequency DBS-related analgesia on neuropathic symptoms using male Sprague-Dawley rats with peripheral nerve injuries to induce neuropathic pain. Rats were divided into four groups, naive, naive + VPL-DBS, neuropathic pain, and neuropathic pain + VPL-DBS. Before and after VPL-DBS, c-fos and GAD65 in the prefrontal cortex, thalamus, and spinal dorsal horn were measured by western blot. In the neuropathic pain + VPL-DBS group, an analgesic effect was observed compared to the neuropathic pain group, and significant c-fos expressions was seen after VPL-DBS in the prefrontal cortex and thalamus. Also, the expressions of GAD65 in the neuropathic pain + VPL-DBS group was slightly higher in the spinal dorsal horn than in the neuropathic pain group, while c-fos expression was decreased. These results suggested that VPL-DBS exerts an effect at both the brain and spinal cord level. High-frequency DBS suppressed the hyper-excited neuronal activities, especially in the prefrontal cortex and thalamus area, and modulate the pain threshold by upregulation of GAD65 expression in spinal dorsal horn. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The effects of deep brain stimulation in neuropathic pain induced rats | - |
dc.title.alternative | 신경병증성 통증 유발 쥐에서 심부뇌자극술의 효과 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Kim, Jae Hyung | - |
dc.type.local | Dissertation | - |
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