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Diverse biological functions of HDAC3 corepressor complexes

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dc.contributor.author최경철-
dc.date.accessioned2015-11-21T07:48:25Z-
dc.date.available2015-11-21T07:48:25Z-
dc.date.issued2010-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/125170-
dc.description의과학과/박사-
dc.description.abstract[한글] [영문]The reversible acetylation by HDAC and HAT is known to be crucial for the stability of p53 and p53-dependent apoptotic signaling. To unravel the functional significance of HDAC3 involved in apoptosis, the yeast-two hybrid assay was performed, and finally identified the proapototic protein, PDCD5 as a novel-HDAC3 interacting protein. Diverse protein-protein interacting analysis found that PDCD5 selectively interacts with HDAC3 among class I HDACs. This study shows that PDCD5-mediated HDAC3 cleavage upon apoptotic stress is dependent on caspase-3. Depletion of either PDCD5 or caspase-3 failed to induce the HDAC3-cleavage and diverse apototic event, indicating that PDCD5-capspase-3 cascade is generally essential for apoptosis. Furthermore, PDCD3-caspase-3 complex directly mediates the ectoposide-induced HDAC3 cleavage and reduction of histone deacetylase activity, and finally increase of cytoplasmic accumulation of HDAC3. More importantly, caspase-3-dependent HDAC3 cleavage by PDCD5 act as a modulator for the maintenance of p53 acetylation and stability.-
dc.description.statementOfResponsibilityprohibition-
dc.publisher연세대학교 대학원-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDiverse biological functions of HDAC3 corepressor complexes-
dc.title.alternativeHDAC3 전사억제자 복합체들의 다양한 생물학적 기능 규명-
dc.typeThesis-
dc.contributor.alternativeNameChoi, Kyung Chul-
dc.type.localDissertation-
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 3. Dissertation

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