The correlation of plasma adiponectin level and infarct size in ST elevation myocardial infarction measured by cardiac magnetic resonance image

Abstract

[영문]Background : Currently, adiponectin is regarded as predicting the risk and prognosis of coronary artery disease. However, it is still unclear whether the level of plasma adiponectin could be useful biomarker for myocardial infarction or not. To demonstrate the controversial factor, the association between adiopnectin after acute myocardial infarction (AMI) and myocardial infarct size measured by cardiac magnetic resonance image (CMRI) were analyzed in this study. Methods : Plasma concentration of adiponectin was measured in 31 patients who underwent successful primary coronary revascularization after acute myocardial infarction (AMI). Blood samples were obtained immediately after admission and at 6, 24, 48, and 72 hours after revascularization. Total LV mass, infarct mass, and microvascular obstruction (MVO) were measured by CMRI and relative infarct mass, relative MVO were calculated. Left ventricular ejection fraction (LVEF) was assessed by echocardiography.Results : After AMI, plasma adiponectin levels did not significantly change compared with the initial level. Plasma concentrations of adiponectin immediately after AMI correlated positively with HDL-cholesterol (r = 0.45, p < 0.05) and negatively with triglyceride (r = -0.41, p < 0.05). During 72 hours after admission, none of the plasma adiponectin levels correlated with a relative infarct mass, relative MVO, or left ventricular ejection fraction.Conclusion : Plasma adiponectin levels during the early phase of myocardial infarction did not correlated with infarct size. Therefore, adiponectin might be not useful as a biomarker for estimating of myocardial damage and systolic function.