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이독성 항생물질이 위액분비 및 실험적 위궤양에 미치는 영향

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dc.description.abstract[한글] [영문] Streptomycin was the first clinically effective drug to become available for the treatment of tuberculosis but many investigators reported labyrinthine and vestibular dysfunction including vertigo, tinnitus, ataxia and hearing loss in the course of tuberculosis therapy with this drug. Thereafter the other aminoglycosides such as neomycin, kanamycin and gentamicin, and also polypeptides of this series, viomycin and capreomycin, were introduced. Nevertheless, all of these drugs showed some degree of similar ototoxicity as it seen in streptomycin. Studies on histopathological changes of inner ear revealed that these antibiotics produced degeneration of internal and external hair cells, and spiral ganglion cell in Corti's organ as well as changes of endolymph pressure in scala media. Moon (1971) reported the circular movement caused a decrease in gastric secretion but failed to decrease after labyrinthectomy or streptomycin treatment. Schapiro et al (1970, 1971) reported visual deprivation or labyrinthectomy caused a marked depression of gastric secretion and concluded that this might result from reduced gastric vagal activity and therefore the parietal cells and the chief cells became less sensitive. Present study was undertaken to observe the effect of various ototoxic antibiotics on the gastric secretory activity and gastric mucosa. One hundred and fifty albino rats of both sexes weighing 200 gm around were divided into two experimental groups. Experiment 1: The following antibiotics, diluted into 10 ml of saline, was injected i.p. 30 minutes prior to procedure: Streptomycin 400 mg/kg, neomycin 200 mg/kg, gentamicin 5 mg/kg or viomycin 100 mg/kg. Control animals were administered either with saline (10 ml/kg) or penicillin(800,000 lU/kg). After ligation of pylorus (Shay operation of the rat) gastric juice was collected for 6 hours. Experiment 2 : The following antibiotics was injected daily for 1 week after same preparation as experiment 1 : Streptomycin 200 mg/kg, neomycin 100 mg/kg, gentamicin 2.5 mg/kg, capreomycin 200 mg/kg, or viomycin 50 mg/kg. After treatment the pylorus of the stomach was ligated for 20 hours. Acidity of gastric juice was determined by consumed amount of NaOH (mEq/L) by means of Titrator TTT 2b with the end point of pH 3 and pH 8 on free acidity and total acidity, respectively. Gastric mucosal changes were observed with stereoscope. The results obtained are summarized as follows : 1. Gastric secretion was significantly inhibited by the treatment with ototoxic antibiotics, especially with neomycin and capreomycin. However with gentamicin the gastric secretion was enhanced. 2. The pH of gastric juice was markedly increased in all groups especially in neomycin and carpreomycin treated group. 3. The concentration of gastric acid was generally decreased, moreover, the free acid in capreomycin treated group was only trace amount. 4. The mucosal changes of the stomach after one week treatment with ototoxic antibiotics were seen on foregut only. The most severe mucosal damage was seen in gentamicin and kanamycin groups but little damage in capreomycin group. By these findings it may be suggested that the ototoxic antibiotics affect the gastric secretion and gastric mucosa greatly and that the more toxic to the ear, the less amount of gastric secretion and the less damage to the gastric mucosa.-
dc.publisher연세대학교 대학원-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title이독성 항생물질이 위액분비 및 실험적 위궤양에 미치는 영향-
dc.title.alternativeEffects of ototoxic antibiotics on gastric secretion and gastric mucosa in rats-
dc.contributor.alternativeNameKim, Won Sup-
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 3. Dissertation


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