Cited 39 times in
Smad-dependent Cooperative Regulation of Interleukin 2 Receptor α Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-β
DC Field | Value | Language |
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dc.contributor.author | 김형표 | - |
dc.date.accessioned | 2015-08-26T16:43:10Z | - |
dc.date.available | 2015-08-26T16:43:10Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114965 | - |
dc.description.abstract | The interleukin 2 receptor alpha chain (IL-2Ralpha) is a component of high affinity IL-2 receptors and thus critically regulates T cell growth and other lymphoid functions. Five positive regulatory regions together control lineage-restricted and activation-dependent IL-2Ralpha induction in response to antigen and IL-2. We now show that TGF-beta cooperates with T cell receptor (TCR) signaling to increase IL-2Ralpha gene expression. Moreover, we identify a sixth positive regulatory region that regulates IL-2Ralpha expression in cells treated with anti-CD3 + anti-CD28 as well as TGF-beta and show that this region contains binding sites for Smad3, AP-1, and cAMP-responsive element-binding protein/ATF proteins. The importance of Smad complexes is indicated by impaired IL-2Ralpha induction by TGF-beta in CD4+ T cells from both Smad3-/- and Smad4-/- mice. Thus, we have identified a novel positive regulatory region in the IL-2Ralpha gene that mediates TGF-beta-dependent induction of the gene. These findings have implications related to IL-2Ralpha expression on activated T cells and regulatory T cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 34042~34047 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Binding Sites | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/physiology | - |
dc.subject.MESH | Gene Expression Regulation* | - |
dc.subject.MESH | Interleukin-2 Receptor alpha Subunit | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Receptors, Interleukin/biosynthesis* | - |
dc.subject.MESH | Receptors, Interleukin/genetics* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Smad Proteins/physiology* | - |
dc.subject.MESH | T-Lymphocytes/physiology | - |
dc.subject.MESH | Transforming Growth Factor beta/physiology* | - |
dc.title | Smad-dependent Cooperative Regulation of Interleukin 2 Receptor α Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-β | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Hyoung-Pyo Kim | - |
dc.contributor.googleauthor | Byung-Gyu Kim | - |
dc.contributor.googleauthor | Warren J. Leonard | - |
dc.contributor.googleauthor | John Letterio | - |
dc.identifier.doi | 10.1074/jbc.M505833200 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01163 | - |
dc.relation.journalcode | J01258 | - |
dc.identifier.eissn | 1083-351X | - |
dc.identifier.pmid | 16087671 | - |
dc.subject.keyword | 16087671 | - |
dc.contributor.alternativeName | Kim, Hyoung Pyo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Pyo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 280 | - |
dc.citation.number | 40 | - |
dc.citation.startPage | 34042 | - |
dc.citation.endPage | 34047 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.280(40) : 34042-34047, 2005 | - |
dc.identifier.rimsid | 39345 | - |
dc.type.rims | ART | - |
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