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만성 요통에 대한 Tramadol 37.5 mg/Acetaminophen 325mg 복합제제와 Cyclo-Oxygenase-2{Celecoxib} 억제제의 유효성 및 안전성 비교 연구 -다기관,무작위 배정,비교 임상 연구-
DC Field | Value | Language |
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dc.contributor.author | 김학선 | - |
dc.contributor.author | 이환모 | - |
dc.date.accessioned | 2015-08-26T16:41:54Z | - |
dc.date.available | 2015-08-26T16:41:54Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1229-5701 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114928 | - |
dc.description.abstract | Study Design: This is a multicenter, randomized comparative outpatient study on a 8-week administration of Tramadol 37.5 mg/Acetaminophen and 325 mg (Tramadol/APAP) combination tablets and Cyclo-Oxygenase-2 inhibitor (Celecoxib). Objectives: We wanted to evaluate the efficacy and safety of Tramadol/APAP combination tablets and Celecoxib for the treatment of chronic low back pain. Summary of the Literature Review:Tramadol/APAP combination tablets have an analgesic efficacy for the treatment of chronic low back pain. The conditions for which COX-2 inhibitors were be used included a variety of musculoskeletal conditions. However, further analyses are needed to determine the efficacy and safety of Tramadol/APAP combination tablets and Celecoxib for the treatment of chronic low back pain. Materials and Methods: One hundred twenty-five patients with chronic low back pain (pain visual analogue scale [VAS] scores >40 mm on 100 mm scale) were randomized to take the Tramadol/APAP combination tablets or Celecoxib for 8 weeks. The primary outcome measure was the pain VAS score, pain relief score and the Korean-version of Oswestry Disability Index (KODI). Results: The study enrolled 125 patients (56 in the Tramadol/APAP tablets group and 69 in the Celecoxib group). There were no significant differences between Tramadol/APAP combination tablets and Celecoxib with regard to the pain VAS scores (VAS; 27.99+/-21.22 vs 24.56+/-16.58, respectively, p>0.05), the pain relief score and the mean decreased disability score on the KODI (0.42+/-0.59 vs 0.46+/-0.05, respectively). The adverse drug reactions showed a statistically significant difference (p<0.05). Conclusions: The results of this study suggest that Tramadol/APAP combination tablets are just as effective as celecoxib for relieving chronic low back pain. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 299~309 | - |
dc.relation.isPartOf | Journal of Korean Society of Spine Surgery (대한척추외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Chronic low back pain | - |
dc.subject.MESH | Tramadol/Acetaminophen | - |
dc.subject.MESH | COX-2 inhibitor | - |
dc.title | 만성 요통에 대한 Tramadol 37.5 mg/Acetaminophen 325mg 복합제제와 Cyclo-Oxygenase-2{Celecoxib} 억제제의 유효성 및 안전성 비교 연구 -다기관,무작위 배정,비교 임상 연구- | - |
dc.title.alternative | omparative Study of the Safety and Effectiveness of Tramadol 37.5 mg/Acetaminophen 325 mg Combined Tablets and Cyclo-Oxygenase-2 (Celecoxib) Inhibitor for the Treatment of Chronic Low Back Pain: A Multicenter, Randomized, Comparative Clinical Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학) | - |
dc.contributor.googleauthor | 전창훈 | - |
dc.contributor.googleauthor | 이환모 | - |
dc.contributor.googleauthor | 민한터 | - |
dc.contributor.googleauthor | 김동준 | - |
dc.contributor.googleauthor | 김동재 | - |
dc.contributor.googleauthor | 박희전 | - |
dc.contributor.googleauthor | 김학선 | - |
dc.contributor.googleauthor | 신동은 | - |
dc.identifier.doi | 10.4184/jkss.2005.12.4.299 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01093 | - |
dc.contributor.localId | A03333 | - |
dc.relation.journalcode | J01550 | - |
dc.identifier.pmid | 10.4184/jkss.2005.12.4.299 | - |
dc.subject.keyword | Chronic low back pain | - |
dc.subject.keyword | Tramadol/Acetaminophen | - |
dc.subject.keyword | COX-2 inhibitor | - |
dc.contributor.alternativeName | Kim, Hak Sun | - |
dc.contributor.alternativeName | Lee, Hwan Mo | - |
dc.contributor.affiliatedAuthor | Kim, Hak Sun | - |
dc.contributor.affiliatedAuthor | Lee, Hwan Mo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 299 | - |
dc.citation.endPage | 309 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Spine Surgery (대한척추외과학회지), Vol.12(4) : 299-309, 2005 | - |
dc.identifier.rimsid | 39316 | - |
dc.type.rims | ART | - |
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