Cited 0 times in
제2형 당뇨병환자에서 Calpain-10 유전자의 다형성과 대사증후군과의 관계
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김경래 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-08-26T16:41:00Z | - |
dc.date.available | 2015-08-26T16:41:00Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1976-9180 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114903 | - |
dc.description.abstract | OBJECTIVE: Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, SNP-19, and SNP-63 of the Calpain 10 gene (CAPN10), have been reported to be associated with the risk of type 2 diabetes (T2DM) in many populations. The aim of this study was to examine the association of the CAPN10 polymorphisms with metabolic syndrome in Korean patients with T2DM. METHODS: Overall, 382 T2DM patients were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, SNP-19 and SNP-63. The restriction fragment length polymorphism method was used for the three SNPs. The baseline presence of the components of metabolic syndrome was determined. RESULTS: 265 (69.4 %) patients were found to have metabolic syndrome. Patients with the 111/121 haplotype combination showed a higher risk of hypertension than the other haplotype combinations (OR=2.334, P=0.010) and also had a significantly higher risk of having metabolic syndrome (OR=1.927, P=0.042). CONCLUSION: The results of this study suggest a role of the novel 111/121 haplotype combination created by the CAPN10 SNPs -43, -19 and -63 in the susceptibility to metabolic syndrome of T2DM patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 451~459 | - |
dc.relation.isPartOf | Journal of Korean Diabetes Association (당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Calpain-10 | - |
dc.subject.MESH | Polymorphism | - |
dc.subject.MESH | Haplotype | - |
dc.subject.MESH | Metabolic Syndrome | - |
dc.title | 제2형 당뇨병환자에서 Calpain-10 유전자의 다형성과 대사증후군과의 관계 | - |
dc.title.alternative | Association of Haplotype Combinations of Calpain-10 Gene Polymorphisms and the Metabolic Syndrome in Type 2 Diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 강은석 | - |
dc.contributor.googleauthor | 김혜주 | - |
dc.contributor.googleauthor | 남문석 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 이유미 | - |
dc.contributor.googleauthor | 명성민 | - |
dc.identifier.doi | OAK-2005-02116 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J01508 | - |
dc.subject.keyword | Calpain-10 | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Haplotype | - |
dc.subject.keyword | Metabolic Syndrome | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Rae | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 459 | - |
dc.identifier.bibliographicCitation | Journal of Korean Diabetes Association (당뇨병), Vol.29(5) : 451-459, 2005 | - |
dc.identifier.rimsid | 39300 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.