Cited 72 times in
Association of the 276G>T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-08-26T16:39:36Z | - |
dc.date.available | 2015-08-26T16:39:36Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114864 | - |
dc.description.abstract | BACKGROUND: The adiponectin gene is known to modulate adiponectin concentrations and diabetes mellitus development. OBJECTIVE: We assessed whether adiponectin gene variants contribute to circulating adiponectin, insulin resistance (IR), or cardiovascular disease risk factors. DESIGN: Nondiabetic subjects [n = 902; x +/- SE age: 42.5 +/- 0.53 y; body mass index (BMI; in kg/m2): 24.7 +/- 0.11] were genotyped for 2 single-nucleotide polymorphisms (SNPs), 45T-->G and 276G-->T. RESULTS: After adjustment for age, sex, and BMI, subjects with the G allele for the SNP 276 had significantly higher concentrations of triacylglycerol and small dense LDL (sdLDL) and smaller LDL particle size than did T/T subjects. G/G subjects at SNP 276 had significantly lower plasma adiponectin and higher homeostasis model assessment (HOMA) of IR and urinary prostaglandin F2alpha than did T/T subjects. In the SNP 45-276 haplotype test, we also observed that subjects with the X/X haplotype had significantly higher plasma adiponectin after adjustment than did TG/TG or TG/X haplotype subjects. In the highest BMI group (BMI > or = 26), T/T subjects had lower HOMA-IR (P = 0.011) and higher plasma adiponectin (P = 0.026) at SNP 276 than did G/G or G/T subjects. These patterns were also seen for adiponectin in haplotype groups. However, no significant genotype effect for SNP 45T-->G was observed. CONCLUSIONS: The 276G-->T polymorphism of the adiponectin gene modulates circulating adiponectin and IR, particularly in obese states. G allele carriers also have higher oxidative stress, higher sdLDL concentrations, and smaller LDL particle size. Therefore, the presence of the G allele in the adiponectin gene at SNP 276 could be a significant contributor to higher cardiovascular disease risk in Koreans, independent of common environmental factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 760~767 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Cardiovascular Diseases/blood | - |
dc.subject.MESH | Cardiovascular Diseases/epidemiology | - |
dc.subject.MESH | Cardiovascular Diseases/genetics* | - |
dc.subject.MESH | Cholesterol, HDL/blood | - |
dc.subject.MESH | Cholesterol, HDL/chemistry | - |
dc.subject.MESH | Cholesterol, LDL/blood | - |
dc.subject.MESH | Cholesterol, LDL/chemistry | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance/genetics* | - |
dc.subject.MESH | Intercellular Signaling Peptides and Proteins/genetics* | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Lipid Peroxidation | - |
dc.subject.MESH | Lipoproteins, LDL/blood* | - |
dc.subject.MESH | Lipoproteins, LDL/chemistry | - |
dc.subject.MESH | Lipoproteins, VLDL/blood | - |
dc.subject.MESH | Lipoproteins, VLDL/chemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.subject.MESH | Triglycerides/chemistry | - |
dc.title | Association of the 276G>T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Jose M Ordovas | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Hongkeun Cho | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Soo Jeong Koh | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.identifier.doi | 10.1093/ajcn/82.4.760 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00074 | - |
dc.identifier.eissn | 1938-3207 | - |
dc.identifier.pmid | 16210704 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | 267G→T | - |
dc.subject.keyword | obesity | - |
dc.subject.keyword | insulin resistance | - |
dc.subject.keyword | cardiovascular disease risk | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 82 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 760 | - |
dc.citation.endPage | 767 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol.82(4) : 760-767, 2005 | - |
dc.identifier.rimsid | 38527 | - |
dc.type.rims | ART | - |
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