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Anaplastic thyroid carcinoma: A therapeutic dilemma

DC Field Value Language
dc.contributor.author남기현-
dc.contributor.author박정수-
dc.contributor.author장항석-
dc.contributor.author정웅윤-
dc.date.accessioned2015-08-26T16:39:20Z-
dc.date.available2015-08-26T16:39:20Z-
dc.date.issued2005-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114856-
dc.description.abstractAnaplastic thyroid carcinoma (ATC) is one of the most malignant human neoplasms and has a grave prognosis. This study gives an update on our experience with this unusual neoplasm, with specific focus on the response to various treatment modalities. Forty-seven patients with histologically proven ATCs were enrolled (19 men, 28 women; mean age, 62.8 years). This number represents 1.5% among a total of 3,088 thyroid cancers treated between 1977 and 2002. The mean tumor diameter was 8.8 cm, and 22 patients had distant metastasis. Extrathyroidal extension was seen in 26 (89.7%) of the cases that underwent surgery. Treatment modalities adopted could be classified into 5 groups: Group 1, biopsy only; Group 2, biopsy and chemoradiotherapy; Group 3, debulking only; Goup 4, debulking and chemoradiotherapy; Group 5, complete excision and chemoradiotherapy. Survival was calculated from the time of diagnosis, and comparisons of survival were done by log-rank analysis. The mean survival was 4.3 months (range, 1.0-21 months). The mean survival based on treatment modalities were as follows: Group 1 (n = 10), 2.1 months, Group 2 (n = 8); 3.6 months; Group 3 (n = 7), 3.0 months; Group 4 (n = 14), 3.5 months, Group 5 (n = 8), 9.4 months. There was no significant difference in survival time between the various types of treatment modalities. Even though a small improvement in survival was observed with complete excision and aggressive multimodality therapy, nearly all ATCs remain unresponsive to ongoing treatment modalities and as such, present a therapeutic dilemma. A more effective treatment regimen should be sought in order to improve survival.-
dc.description.statementOfResponsibilityopen-
dc.format.extent759~764-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma/mortality-
dc.subject.MESHCarcinoma/surgery-
dc.subject.MESHCarcinoma/therapy*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHThyroid Neoplasms/mortality-
dc.subject.MESHThyroid Neoplasms/surgery-
dc.subject.MESHThyroid Neoplasms/therapy*-
dc.subject.MESHTreatment Outcome-
dc.titleAnaplastic thyroid carcinoma: A therapeutic dilemma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorHang-Seok Chang-
dc.contributor.googleauthorKee-Hyun Nam-
dc.contributor.googleauthorCheong Soo Park-
dc.contributor.googleauthorWoung Youn Chung-
dc.identifier.doi10.3349/ymj.2005.46.6.759-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01646-
dc.contributor.localIdA01245-
dc.contributor.localIdA03488-
dc.contributor.localIdA03674-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid16385650-
dc.subject.keywordAnaplastic thyroid cancer-
dc.subject.keywordtreatment modalities-
dc.subject.keywordtreatment outcome-
dc.contributor.alternativeNameNam, Kee Hyun-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameChang, Hang Seok-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.affiliatedAuthorPark, Cheong Soo-
dc.contributor.affiliatedAuthorNam, Kee Hyun-
dc.contributor.affiliatedAuthorChang, Hang Seok-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.rights.accessRightsfree-
dc.citation.volume46-
dc.citation.number6-
dc.citation.startPage759-
dc.citation.endPage764-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.46(6) : 759-764, 2005-
dc.identifier.rimsid38521-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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