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Chronologically different impacts of immunologic and non-immunologic risk factors on renal allograft function

DC Field Value Language
dc.contributor.author김동기-
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author명성민-
dc.contributor.author박기일-
dc.contributor.author오창권-
dc.contributor.author이종훈-
dc.contributor.author강신욱-
dc.date.accessioned2015-08-26T16:35:21Z-
dc.date.available2015-08-26T16:35:21Z-
dc.date.issued2005-
dc.identifier.issn0902-0063-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114750-
dc.description.abstractINTRODUCTION: Upon analysis of the risk factors affecting renal graft survival and function, the time-dependent effects of each risk factor should be differentiated from their net effects. To evaluate the chronologically different impacts of risk factors on graft renal function, we reviewed 390 recipients who received a kidney from 1-haplotype-matched living-related donors. MATERIALS AND METHODS: Until 5-yr post-transplantation (TX), yearly serum creatinine (Scr), 24-h urinary excretion of protein, and their yearly changes were compared by the episodes of acute rejection within 1 yr, the kidney weight to recipient body weight (KW/BW) ratio, the donor/recipient (D/R) age ratio, and the D/R gender pairing. The Kaplan-Meier method, Cox proportional hazard model, ANOVA, and repeated measures ANOVA were each applied for different purposes. RESULTS: Only the episodes of acute rejection were a significant risk factor affecting graft survival. The episodes of acute rejection, KW/BW ratio, D/R age ratio, and D/R gender pairing consistently and independently had significant influences on Scr. Recipients having the lowest KW/BW ratio (first quartile) or the highest D/R age ratio (fourth quartile) had rapid increments of Scr after 4-yr post-TX. After 3-yr post-TX, there were significant correlations between the number of non-immunologic risk factors present and the yearly changes in Scr. CONCLUSIONS: Non-immunologic factors had a detrimental effect on renal graft function, especially after 3-yr post-TX. If immunologic risks seem to be similar, size matching, age, and gender pairing should be considered for better long-term graft function in renal TX recipients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent742~750-
dc.relation.isPartOfCLINICAL TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Factors-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/epidemiology-
dc.subject.MESHGraft Survival-
dc.subject.MESHHumans-
dc.subject.MESHKidney Function Tests-
dc.subject.MESHKidney Transplantation*/immunology-
dc.subject.MESHKidney Transplantation*/mortality-
dc.subject.MESHMale-
dc.subject.MESHOrgan Size-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleChronologically different impacts of immunologic and non-immunologic risk factors on renal allograft function-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorDong Kee Kim-
dc.contributor.googleauthorKiil Park-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorJong Hoon Lee-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorChang-Kwon Oh-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorSung Min Myoung-
dc.identifier.doi10.1111/j.1399-0012.2005.00414.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA01349-
dc.contributor.localIdA01448-
dc.contributor.localIdA02404-
dc.contributor.localIdA03156-
dc.contributor.localIdA00053-
dc.contributor.localIdA00424-
dc.contributor.localIdA00399-
dc.relation.journalcodeJ00615-
dc.identifier.eissn1399-0012-
dc.identifier.pmid16313319-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1399-0012.2005.00414.x/abstract-
dc.subject.keywordage factors-
dc.subject.keywordkidney transplantation-
dc.subject.keywordnephron mass-
dc.subject.keywordrenal function-
dc.subject.keywordrisk factors-
dc.contributor.alternativeNameKim, Dong Ki-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameMyoung, Sung Min-
dc.contributor.alternativeNamePark, Ki Il-
dc.contributor.alternativeNameOh, Chang Kwon-
dc.contributor.alternativeNameLee, Jong Hoon-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorMyoung, Sung Min-
dc.contributor.affiliatedAuthorPark, Ki Il-
dc.contributor.affiliatedAuthorOh, Chang Kwon-
dc.contributor.affiliatedAuthorLee, Jong Hoon-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.contributor.affiliatedAuthorKim, Dong Ki-
dc.rights.accessRightsnot free-
dc.citation.volume19-
dc.citation.number6-
dc.citation.startPage742-
dc.citation.endPage750-
dc.identifier.bibliographicCitationCLINICAL TRANSPLANTATION, Vol.19(6) : 742-750, 2005-
dc.identifier.rimsid46096-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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