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Autologous mesenchymal stem cell transplantation in stroke patients

DC Field Value Language
dc.contributor.author이필휴-
dc.date.accessioned2015-08-26T16:35:01Z-
dc.date.available2015-08-26T16:35:01Z-
dc.date.issued2005-
dc.identifier.issn0364-5134-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114741-
dc.description.abstractMesenchymal stem cell (MSC) transplantation improves recovery from ischemic stroke in animals. We examined the feasibility, efficacy, and safety of cell therapy using culture-expanded autologous MSCs in patients with ischemic stroke. We prospectively and randomly allocated 30 patients with cerebral infarcts within the middle cerebral arterial territory and with severe neurological deficits into one of two treatment groups: the MSC group (n = 5) received intravenous infusion of 1 × 108 autologous MSCs, whereas the control group (n = 25) did not receive MSCs. Changes in neurological deficits and improvements in function were compared between the groups for 1 year after symptom onset. Neuroimaging was performed serially in five patients from each group. Outcomes improved in MSC-treated patients compared with the control patients: the Barthel index (p = 0.011, 0.017, and 0.115 at 3, 6, and 12 months, respectively) and modified Rankin score (p = 0.076, 0.171, and 0.286 at 3, 6, and 12 months, respectively) of the MSC group improved consistently during the follow-up period. Serial evaluations showed no adverse cell-related, serological, or imaging-defined effects. In patients with severe cerebral infarcts, the intravenous infusion of autologous MSCs appears to be a feasible and safe therapy that may improve functional recovery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent874~882-
dc.relation.isPartOfANNALS OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCells, Cultured-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInfarction, Middle Cerebral Artery/pathology-
dc.subject.MESHInfarction, Middle Cerebral Artery/therapy*-
dc.subject.MESHInjections, Intravenous-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMesoderm/cytology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRecovery of Function-
dc.subject.MESHStem Cell Transplantation*/adverse effects-
dc.subject.MESHTransplantation, Autologous-
dc.subject.MESHTreatment Outcome-
dc.titleAutologous mesenchymal stem cell transplantation in stroke patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorOh Young Bang-
dc.contributor.googleauthorJin Soo Lee-
dc.contributor.googleauthorGwang Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1002/ana.20501-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03270-
dc.relation.journalcodeJ00166-
dc.identifier.eissn1531-8249-
dc.identifier.pmid15929052-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ana.20501/abstract-
dc.subject.keyword15929052-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.rights.accessRightsnot free-
dc.citation.volume57-
dc.citation.number6-
dc.citation.startPage874-
dc.citation.endPage882-
dc.identifier.bibliographicCitationANNALS OF NEUROLOGY, Vol.57(6) : 874-882, 2005-
dc.identifier.rimsid46089-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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