Cited 18 times in
Fractal Stochastic Modeling of Spiking Activity in Suprachiasmatic Nucleus Neurons
DC Field | Value | Language |
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dc.contributor.author | 곽용호 | - |
dc.date.accessioned | 2015-08-26T16:34:52Z | - |
dc.date.available | 2015-08-26T16:34:52Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0929-5313 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114737 | - |
dc.description.abstract | Individual neurons in the suprachiasmatic nucleus (SCN), the master biological clock in mammals, autonomously produce highly complex patterns of spikes. We have shown that most (~90%) SCN neurons exhibit truly stochastic interspike interval (ISI) patterns. The aim of this study was to understand the stochastic nature of the firing patterns in SCN neurons by analyzing the ISI sequences of 150 SCN neurons in hypothalamic slices. Fractal analysis, using the periodogram, Fano factor, and Allan factor, revealed the presence of a 1/f-type power-law (fractal) behavior in the ISI sequences. This fractal nature was persistent after the application of the GABAA receptor antagonist bicuculline, suggesting that the fractal stochastic activity is an intrinsic property of individual SCN neurons. Based on these physiological findings, we developed a computational model for the stochastic SCN neurons to find that their stochastic spiking activity was best described by a gamma point process whose mean firing rate was modulated by a fractal binomial noise. Taken together, we suggest that SCN neurons generate temporal spiking patterns using the fractal stochastic point process. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 39~51 | - |
dc.relation.isPartOf | JOURNAL OF COMPUTATIONAL NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Action Potentials/drug effects | - |
dc.subject.MESH | Action Potentials/physiology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bicuculline/pharmacology | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | GABA Antagonists/pharmacology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Models, Neurological* | - |
dc.subject.MESH | Neurons/drug effects | - |
dc.subject.MESH | Neurons/physiology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stochastic Processes* | - |
dc.subject.MESH | Suprachiasmatic Nucleus/cytology* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Fractal Stochastic Modeling of Spiking Activity in Suprachiasmatic Nucleus Neurons | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Sung-IL Kim | - |
dc.contributor.googleauthor | Jaeseung Jeong | - |
dc.contributor.googleauthor | Kyoung J. Lee | - |
dc.contributor.googleauthor | Seung Hun Jung | - |
dc.contributor.googleauthor | Yang In Kim | - |
dc.contributor.googleauthor | Yongho Kwak | - |
dc.identifier.doi | 10.1007/s10827-005-0149-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00175 | - |
dc.relation.journalcode | J01349 | - |
dc.identifier.eissn | 1573-6873 | - |
dc.identifier.pmid | 16133824 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10827-005-0149-x | - |
dc.subject.keyword | suprachiasmatic nucleus | - |
dc.subject.keyword | interspike intervals | - |
dc.subject.keyword | fractal | - |
dc.subject.keyword | stochastic | - |
dc.subject.keyword | gamma point processes | - |
dc.subject.keyword | long-term correlations | - |
dc.contributor.alternativeName | Kwak, Yong Ho | - |
dc.contributor.affiliatedAuthor | Kwak, Yong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COMPUTATIONAL NEUROSCIENCE, Vol.19(1) : 39-51, 2005 | - |
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