Cited 415 times in
Discrepancy Between the Tuberculin Skin Test and the Whole-Blood Interferon γ Assay for the Diagnosis of Latent Tuberculosis Infection in an Intermediate Tuberculosis-Burden Country
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.date.accessioned | 2015-08-26T16:34:30Z | - |
dc.date.available | 2015-08-26T16:34:30Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0098-7484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114728 | - |
dc.description.abstract | CONTEXT: A recently developed whole-blood interferon gamma (IFN-gamma) assay based on stimulation with the Mycobacterium tuberculosis-specific antigens early secreted antigenic target 6 and culture filtrate protein 10 shows promise for the diagnosis of latent tuberculosis (TB) infection. OBJECTIVE: To compare the tuberculin skin test (TST) and the whole-blood IFN-gamma assay in the diagnosis of latent TB infection according to the intensity of exposure. DESIGN AND SETTING: A prospective comparison between the whole-blood IFN-gamma assay and the TST using a 2-TU dose of purified protein derivative RT23 in a population with intermediate TB burden was conducted sequentially between February 1, 2004, and February 28, 2005, in a Korean tertiary referral hospital. PARTICIPANTS: Of 273 participants, 220 (95.7%) had received BCG vaccine. Participants were grouped according to their risk of infection: group 1, no identifiable risk of M tuberculosis infection (n = 99); group 2, recent casual contacts (n = 72); group 3, recent close contacts (n = 48); group 4, bacteriologically or pathologically confirmed TB patients (n = 54). MAIN OUTCOME MEASURES: Levels of agreement between the TST and the IFN-gamma assay and the likelihood of infection in the various groups. RESULTS: For the TST with a 10-mm induration cutoff, the positive response rate in group 1 was 51%; group 2, 60%; group 3, 71%, and group 4, 78%. For the IFN-gamma assay, the positive response rate in group 1 was 4%; group 2, 10%; group 3, 44%; and group 4, 81%. The overall agreement between the TST and the IFN-gamma assay in healthy volunteers was kappa = 0.16. The odds of a positive test result per unit increase in exposure across the 4 groups increased by a factor of 5.31 (95% confidence interval [CI], 3.62-7.79) for the IFN-gamma assay and by a factor of 1.52 (95% CI, 1.20-1.91) for the TST (P<.001). Using a 15-mm induration cutoff for the TST did not make a substantial difference to the test results. CONCLUSION: The IFN-gamma assay is a better indicator of the risk of M tuberculosis infection than TST in a BCG-vaccinated population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2756~2761 | - |
dc.relation.isPartOf | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, Bacterial/immunology | - |
dc.subject.MESH | BCG Vaccine | - |
dc.subject.MESH | Bacterial Proteins/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/immunology* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology | - |
dc.subject.MESH | Mycobacterium tuberculosis/isolation & purification* | - |
dc.subject.MESH | Mycobacterium tuberculosis/physiology | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Tuberculin Test* | - |
dc.subject.MESH | Tuberculosis, Pulmonary/diagnosis* | - |
dc.subject.MESH | Tuberculosis, Pulmonary/immunology | - |
dc.subject.MESH | Virus Latency | - |
dc.title | Discrepancy Between the Tuberculin Skin Test and the Whole-Blood Interferon γ Assay for the Diagnosis of Latent Tuberculosis Infection in an Intermediate Tuberculosis-Burden Country | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Jae-Joon Yim | - |
dc.contributor.googleauthor | Young-Soo Shim | - |
dc.contributor.googleauthor | Sung Koo Han | - |
dc.contributor.googleauthor | BeLong Cho | - |
dc.contributor.googleauthor | Ho Il Yoon | - |
dc.identifier.doi | 10.1001/jama.293.22.2756 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00057 | - |
dc.relation.journalcode | J01196 | - |
dc.identifier.eissn | 1538-3598 | - |
dc.identifier.pmid | 15941805 | - |
dc.identifier.url | http://jama.jamanetwork.com/article.aspx?articleid=201039 | - |
dc.subject.keyword | 15941805 | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 293 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 2756 | - |
dc.citation.endPage | 2761 | - |
dc.identifier.bibliographicCitation | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol.293(22) : 2756-2761, 2005 | - |
dc.identifier.rimsid | 46080 | - |
dc.type.rims | ART | - |
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