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Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

DC FieldValueLanguage
dc.contributor.author남기택-
dc.date.accessioned2015-07-15T17:20:00Z-
dc.date.available2015-07-15T17:20:00Z-
dc.date.issued2003-
dc.identifier.issn0264-0414-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114694-
dc.description.abstractIn its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent943~951-
dc.relation.isPartOfJOURNAL OF SPORTS SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlzheimer Disease/genetics*-
dc.subject.MESHAlzheimer Disease/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHBehavior, Animal/physiology-
dc.subject.MESHBlotting, Western-
dc.subject.MESHBrain/metabolism-
dc.subject.MESHCholesterol/blood-
dc.subject.MESHCholesterol, HDL/blood-
dc.subject.MESHCholesterol, LDL/blood-
dc.subject.MESHFemale-
dc.subject.MESHMale-
dc.subject.MESHMaze Learning/physiology-
dc.subject.MESHMembrane Proteins/genetics*-
dc.subject.MESHMice-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHMuscle, Skeletal/metabolism-
dc.subject.MESHPhosphopyruvate Hydratase/genetics*-
dc.subject.MESHPhysical Conditioning, Animal/physiology*-
dc.subject.MESHPresenilin-2-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHTriglycerides/blood-
dc.titleUse of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorJun Y Cho-
dc.contributor.googleauthorDae Y Hwang-
dc.contributor.googleauthorYong K Kim-
dc.contributor.googleauthorJung S Cho-
dc.contributor.googleauthorKyu S Lee-
dc.contributor.googleauthorKi T Nam-
dc.contributor.googleauthorYoun S Song-
dc.contributor.googleauthorSu J Seo-
dc.contributor.googleauthorSae H Min-
dc.contributor.googleauthorHwa J Lim-
dc.contributor.googleauthorSu H Lee-
dc.contributor.googleauthorChae H Lim-
dc.contributor.googleauthorJin H Hwang-
dc.contributor.googleauthorDong H Shin-
dc.contributor.googleauthorTae S Kang-
dc.identifier.doi10.1080/0264041031000140365-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01243-
dc.relation.journalcodeJ01756-
dc.identifier.eissn1466-447X-
dc.identifier.pmid14626374-
dc.identifier.urlhttp://www.tandfonline.com/doi/abs/10.1080/0264041031000140365#.U84aN6izIyo-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordcholesterol-
dc.subject.keywordexercise-
dc.subject.keywordpresenilin-
dc.subject.keywordsports-
dc.subject.keywordtransgenic-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthorNam, Ki Taek-
dc.rights.accessRightsnot free-
dc.citation.volume21-
dc.citation.number11-
dc.citation.startPage943-
dc.citation.endPage951-
dc.identifier.bibliographicCitationJOURNAL OF SPORTS SCIENCES, Vol.21(11) : 943-951, 2003-
dc.identifier.rimsid46066-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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