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Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

Authors
 Jun Y Cho  ;  Dae Y Hwang  ;  Yong K Kim  ;  Jung S Cho  ;  Kyu S Lee  ;  Ki T Nam  ;  Youn S Song  ;  Su J Seo  ;  Sae H Min  ;  Hwa J Lim  ;  Su H Lee  ;  Chae H Lim  ;  Jin H Hwang  ;  Dong H Shin  ;  Tae S Kang 
Citation
 JOURNAL OF SPORTS SCIENCES, Vol.21(11) : 943-951, 2003 
Journal Title
JOURNAL OF SPORTS SCIENCES
ISSN
 0264-0414 
Issue Date
2003
MeSH
Alzheimer Disease/genetics* ; Alzheimer Disease/metabolism* ; Animals ; Behavior, Animal/physiology ; Blotting, Western ; Brain/metabolism ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Female ; Male ; Maze Learning/physiology ; Membrane Proteins/genetics* ; Mice ; Mice, Transgenic ; Muscle, Skeletal/metabolism ; Phosphopyruvate Hydratase/genetics* ; Physical Conditioning, Animal/physiology* ; Presenilin-2 ; Reverse Transcriptase Polymerase Chain Reaction ; Triglycerides/blood
Keywords
Alzheimer's disease ; cholesterol ; exercise ; presenilin ; sports ; transgenic
Abstract
In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/0264041031000140365#.U84aN6izIyo
DOI
10.1080/0264041031000140365
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114694
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