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ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients: effect of ACE gene DD on the progression of diabetic nephropathy.

DC Field Value Language
dc.contributor.author김도훈-
dc.contributor.author박형천-
dc.contributor.author이태희-
dc.contributor.author이호영-
dc.contributor.author최규헌-
dc.contributor.author하성규-
dc.contributor.author한대석-
dc.contributor.author강병승-
dc.contributor.author강신욱-
dc.date.accessioned2015-07-15T17:19:51Z-
dc.date.available2015-07-15T17:19:51Z-
dc.date.issued2003-
dc.identifier.issn0272-6386-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114689-
dc.description.abstractBACKGROUND: Pathophysiological causes of the development and progression of diabetic nephropathy are not well known, but the angiotensin-converting enzyme (ACE) gene polymorphism has been proposed to be involved in its development and progression. METHODS: The impact of insertion/deletion (I/D) genotypes on the progression of diabetic nephropathy in 239 Korean patients with type 2 diabetes (99 patients with stable renal function, group 1; 140 patients with declining renal function, group 2) was investigated by retrospective review of clinical data. RESULTS: The frequency of the DD genotype was significantly greater in group 2 compared with group 1 (30.7% versus 9.1%; P < 0.05). There were no significant differences in age, blood pressure, hemoglobin A(1c) levels, or lipid profiles among ACE genotype groups. However, the prevalence of retinopathy was significantly greater in patients with the DD genotype (DD, ID, and II, 90.4%, 71.2%, and 70.6%, respectively; P < 0.05). Patients with the DD genotype reached the end point (serum creatinine > 2.0 mg/dL [176.8 micromol/L]) faster than those with the other genotypes (DD, 11.38 +/- 4.08 years; ID, 13.85 +/- 4.04 years; II, 14.04 +/- 4.06 years, respectively; P < 0.05) and took significantly less time to reach dialysis therapy (DD, 13.10 +/- 4.45 years; ID, 16.21 +/- 4.74 years; II, 15.13 +/- 4.09 years, respectively; P < 0.05). In multiple logistic regression analysis, systolic blood pressure and DD genotype showed significant correlations with the progression of diabetic nephropathy. In patients with the DD genotype, the odds ratio was 3.881 (95% confidence interval, 1.564 approximately 9.628; P = 0.003) compared with those with the II genotype. CONCLUSION: It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent943~949-
dc.relation.isPartOfAMERICAN JOURNAL OF KIDNEY DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHDiabetes Mellitus, Type 2/complications-
dc.subject.MESHDiabetes Mellitus, Type 2/genetics*-
dc.subject.MESHDiabetic Nephropathies/etiology-
dc.subject.MESHDiabetic Nephropathies/genetics*-
dc.subject.MESHDiabetic Nephropathies/therapy-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHGene Deletion-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeptidyl-Dipeptidase A/genetics*-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHRenal Dialysis-
dc.titleACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients: effect of ACE gene DD on the progression of diabetic nephropathy.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSung-Kyu Ha-
dc.contributor.googleauthorHyeong Cheon Park-
dc.contributor.googleauthorDae Suk Han-
dc.contributor.googleauthorHo Yung Lee-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorShin Wook Kang-
dc.contributor.googleauthorDo Hun Kim-
dc.contributor.googleauthorSeung Jung Kim-
dc.contributor.googleauthorHak Jin Hwang-
dc.contributor.googleauthorTae Hee Lee-
dc.contributor.googleauthorByung Seung Kang-
dc.contributor.googleauthorHong Su Park-
dc.identifier.doi10.1016/S0272-6386(03)00191-4-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01759-
dc.contributor.localIdA03266-
dc.contributor.localIdA03326-
dc.contributor.localIdA04043-
dc.contributor.localIdA04252-
dc.contributor.localIdA04272-
dc.contributor.localIdA00030-
dc.contributor.localIdA00053-
dc.contributor.localIdA00392-
dc.relation.journalcodeJ00089-
dc.identifier.eissn1523-6838-
dc.identifier.pmid12722028-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0272638603001914-
dc.subject.keywordAngiotensin-converting enzyme (ACE) gene-
dc.subject.keywordprogression-
dc.subject.keyworddiabetic nephropathy-
dc.contributor.alternativeNameKim, Do Hoon-
dc.contributor.alternativeNamePark, Hyeong Cheon-
dc.contributor.alternativeNameLee, Tae Hee-
dc.contributor.alternativeNameLee, Ho Yung-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHa, Sung Kyu-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameKang, Byung Seung-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthorPark, Hyeong Cheon-
dc.contributor.affiliatedAuthorLee, Tae Hee-
dc.contributor.affiliatedAuthorLee, Ho Yung-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHa, Sung Kyu-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorKang, Byung Seung-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKim, Do Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume41-
dc.citation.number5-
dc.citation.startPage943-
dc.citation.endPage949-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF KIDNEY DISEASES, Vol.41(5) : 943-949, 2003-
dc.identifier.rimsid46061-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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