Cited 49 times in
Effect of losartan and amlodipine on proteinuria and transforming growth factor‐β1 in patients with IgA nephropathy
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 구영석 | - |
dc.contributor.author | 박형천 | - |
dc.contributor.author | 이호영 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 최소래 | - |
dc.contributor.author | 하성규 | - |
dc.contributor.author | 한대석 | - |
dc.date.accessioned | 2015-07-15T17:19:49Z | - |
dc.date.available | 2015-07-15T17:19:49Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114688 | - |
dc.description.abstract | BACKGROUND: Transforming growth factor-beta1 (TGF-beta1) is the major profibrotic cytokine involved in many renal diseases, and urinary TGF-beta1 reflects intrarenal TGF-beta1 production. Urinary TGF-beta1 excretion is reported to be significantly increased in patients with immunoglobulin A (IgA) nephropathy. The aim of the present study was to compare the effects of losartan and amlodipine on proteinuria, as well as on serum and urine TGF-beta1 levels in IgA nephropathy patients with hypertension and proteinuria. METHODS: The initial 4 week washout period was followed by 12 weeks of active treatment, in which patients were randomized to once-daily treatment with losartan 50 mg (group 1, n=20) or amlodipine 5 mg (group 2, n=16). Urinary protein and TGF-beta1 excretion, serum TGF-beta1 and other clinical parameters were determined at baseline and during 12 weeks of active treatment. RESULTS: Both treatments controlled blood pressure (BP) to a similar degree, and renal function and other biochemical parameters did not change during the study period. Urinary protein and TGF-beta1 excretions were significantly elevated in IgA nephropathy patients. Losartan significantly reduced urinary protein (from 2.3+/-1.5 g/day at baseline to 1.2+/-1.5 g/day at 12 weeks, P<0.05) and urinary TGF-beta1 excretion (from 31.2+/-14.0 pg/mg creatinine at baseline to 22.1+/-13.5 pg/mg creatinine at 12 weeks, P<0.05). In contrast, amlodipine had no affect on urinary protein and TGF-beta1 excretion. Both losartan and amlodipine failed to reduce serum TGF-beta1 levels. CONCLUSION: Losartan and amlodipine, with similar control of BP, showed different effects on urine protein or TGF-beta1 excretion. Whereas losartan improved both urinary parameters, amlodipine did not. These differences might be important for the management of IgA nephropathy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1115~1121 | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Amlodipine/pharmacology* | - |
dc.subject.MESH | Amlodipine/therapeutic use | - |
dc.subject.MESH | Antihypertensive Agents/pharmacology* | - |
dc.subject.MESH | Antihypertensive Agents/therapeutic use | - |
dc.subject.MESH | Blood Pressure/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerulonephritis, IGA/complications | - |
dc.subject.MESH | Glomerulonephritis, IGA/drug therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/complications | - |
dc.subject.MESH | Hypertension/drug therapy* | - |
dc.subject.MESH | Losartan/pharmacology* | - |
dc.subject.MESH | Losartan/therapeutic use | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proteinuria/etiology | - |
dc.subject.MESH | Proteinuria/prevention & control* | - |
dc.subject.MESH | Transforming Growth Factor beta/blood | - |
dc.subject.MESH | Transforming Growth Factor beta/drug effects* | - |
dc.subject.MESH | Transforming Growth Factor beta/urine | - |
dc.subject.MESH | Transforming Growth Factor beta1 | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effect of losartan and amlodipine on proteinuria and transforming growth factor‐β1 in patients with IgA nephropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyeong Cheon Park | - |
dc.contributor.googleauthor | Zhong Gao Xu | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.contributor.googleauthor | Ho Yung Lee | - |
dc.contributor.googleauthor | Sung Kyu Ha | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Shin Wook Kang | - |
dc.contributor.googleauthor | Young Suck Goo | - |
dc.contributor.googleauthor | Sorae Choi | - |
dc.identifier.doi | 10.1093/ndt/gfg090 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00197 | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A03326 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A04252 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A04088 | - |
dc.relation.journalcode | J02316 | - |
dc.identifier.eissn | 1460-2385 | - |
dc.identifier.pmid | 12748343 | - |
dc.subject.keyword | amlopidine | - |
dc.subject.keyword | IgA nephropathy | - |
dc.subject.keyword | losartan | - |
dc.subject.keyword | proteinuria | - |
dc.subject.keyword | transforming growth factor-β1 | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Goo, Young Suck | - |
dc.contributor.alternativeName | Park, Hyeong Cheon | - |
dc.contributor.alternativeName | Lee, Ho Yung | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.alternativeName | Choi, So Rae | - |
dc.contributor.alternativeName | Ha, Sung Kyu | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Goo, Young Suck | - |
dc.contributor.affiliatedAuthor | Park, Hyeong Cheon | - |
dc.contributor.affiliatedAuthor | Lee, Ho Yung | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Choi, Sorae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1115 | - |
dc.citation.endPage | 1121 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.18(6) : 1115-1121, 2003 | - |
dc.identifier.rimsid | 46060 | - |
dc.type.rims | ART | - |
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