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색소성 피부질환에 대한 큐스위치 알렉산드라이트 레이저 치료직후의 조직, 면역조직화학, 전자현미경적 소견.

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dc.contributor.author방동식-
dc.date.accessioned2015-07-15T17:11:49Z-
dc.date.available2015-07-15T17:11:49Z-
dc.date.issued2003-
dc.identifier.issn0494-4739-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114423-
dc.description.abstractBackground : There have been only a few electron microscopic studies after laser treatment of pigmented skin lesions. Objective : The purpose was to investigate the pathologic, immunohistochemical, and electron microscopic changes following Q-switched alexandrite laser treatment of pigmented skin lesions. Methods : Three patients with acquired bilateral nevus of Ota-like macules, and 2 patients with cafe´au lait macule were irradiated with Q-switched alexandrite laser. Forty biopsies were taken before and immediately after laser treatment. Hematoxylin-eosin, Fontana-Masson, and gp100 staining were performed for the evaluation of the histopathologic and immunohistochemical findings of the specimens. Electron microscopic findings were also evaluated. Results : Histopathologically, suprabasilar separations were observed immediately after laser treatment. Vacuolar alterations of pigment-containing cells were frequently found in the epidermis and/or in the dermis. Fontana-Masson and gp100 staining positivity changed to negative or decreased in the epidermis immediately after laser treatment, while they changed to negative in the dermis. Ultrastructurally, epidermal pigment-containing cells frequently showed severe vacuolar changes in the cytoplasm, pyknotic nuclei, and vacuolated and/or fragmented melanosomes immediately after laser treatment. Dermal melanocytes frequently revealed vacuolated and/or fragmented melanosomes immediately after laser treatment. Conclusion : Histopathologic, immunohistochemical, and electron microscopic examination of pigmented skin lesions immediately after Q-switched alexandrite laser treatment demonstrated vacuolated or fragmented melanosomes and vacuolar alteration of pigment-containing cells in the epidermis and/or in the dermis, which suggested selective photothermolysis of melanosomes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1014~1021-
dc.relation.isPartOfKorean Journal of Dermatology (대한피부과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHelectron microscopic-
dc.subject.MESHpigmented skin lesions-
dc.subject.MESHQ-switched alexandrite laser-
dc.title색소성 피부질환에 대한 큐스위치 알렉산드라이트 레이저 치료직후의 조직, 면역조직화학, 전자현미경적 소견.-
dc.title.alternativeHistopathologic, Immunohistochemical, and Electron Microscopic Findings of Pigmented Skin Lesions Immediately after Q-switched Alexandrite Laser Treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthor김유찬-
dc.contributor.googleauthor강원형-
dc.contributor.googleauthor이정구-
dc.contributor.googleauthor명나혜-
dc.contributor.googleauthor방동식-
dc.identifier.doiOAK-2003-01263-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.relation.journalcodeJ02000-
dc.subject.keywordelectron microscopic-
dc.subject.keywordpigmented skin lesions-
dc.subject.keywordQ-switched alexandrite laser-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.rights.accessRightsfree-
dc.citation.volume41-
dc.citation.number8-
dc.citation.startPage1014-
dc.citation.endPage1021-
dc.identifier.bibliographicCitationKorean Journal of Dermatology (대한피부과학회지), Vol.41(8) : 1014-1021, 2003-
dc.identifier.rimsid47661-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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