Cited 0 times in
색소성 피부질환에 대한 큐스위치 알렉산드라이트 레이저 치료직후의 조직, 면역조직화학, 전자현미경적 소견.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 방동식 | - |
dc.date.accessioned | 2015-07-15T17:11:49Z | - |
dc.date.available | 2015-07-15T17:11:49Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114423 | - |
dc.description.abstract | Background : There have been only a few electron microscopic studies after laser treatment of pigmented skin lesions. Objective : The purpose was to investigate the pathologic, immunohistochemical, and electron microscopic changes following Q-switched alexandrite laser treatment of pigmented skin lesions. Methods : Three patients with acquired bilateral nevus of Ota-like macules, and 2 patients with cafe´au lait macule were irradiated with Q-switched alexandrite laser. Forty biopsies were taken before and immediately after laser treatment. Hematoxylin-eosin, Fontana-Masson, and gp100 staining were performed for the evaluation of the histopathologic and immunohistochemical findings of the specimens. Electron microscopic findings were also evaluated. Results : Histopathologically, suprabasilar separations were observed immediately after laser treatment. Vacuolar alterations of pigment-containing cells were frequently found in the epidermis and/or in the dermis. Fontana-Masson and gp100 staining positivity changed to negative or decreased in the epidermis immediately after laser treatment, while they changed to negative in the dermis. Ultrastructurally, epidermal pigment-containing cells frequently showed severe vacuolar changes in the cytoplasm, pyknotic nuclei, and vacuolated and/or fragmented melanosomes immediately after laser treatment. Dermal melanocytes frequently revealed vacuolated and/or fragmented melanosomes immediately after laser treatment. Conclusion : Histopathologic, immunohistochemical, and electron microscopic examination of pigmented skin lesions immediately after Q-switched alexandrite laser treatment demonstrated vacuolated or fragmented melanosomes and vacuolar alteration of pigment-containing cells in the epidermis and/or in the dermis, which suggested selective photothermolysis of melanosomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | electron microscopic | - |
dc.subject.MESH | pigmented skin lesions | - |
dc.subject.MESH | Q-switched alexandrite laser | - |
dc.title | 색소성 피부질환에 대한 큐스위치 알렉산드라이트 레이저 치료직후의 조직, 면역조직화학, 전자현미경적 소견. | - |
dc.title.alternative | Histopathologic, Immunohistochemical, and Electron Microscopic Findings of Pigmented Skin Lesions Immediately after Q-switched Alexandrite Laser Treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 김유찬 | - |
dc.contributor.googleauthor | 강원형 | - |
dc.contributor.googleauthor | 이정구 | - |
dc.contributor.googleauthor | 명나혜 | - |
dc.contributor.googleauthor | 방동식 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01784 | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | electron microscopic | - |
dc.subject.keyword | pigmented skin lesions | - |
dc.subject.keyword | Q-switched alexandrite laser | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | Bang, Dong Sik | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1014 | - |
dc.citation.endPage | 1021 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.41(8) : 1014-1021, 2003 | - |
dc.identifier.rimsid | 47661 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.