Cited 61 times in
Microinjection of CART peptide 55–102 into the nucleus accumbens blocks amphetamine-induced locomotion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정훈 | - |
dc.date.accessioned | 2015-07-15T17:10:32Z | - |
dc.date.available | 2015-07-15T17:10:32Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0143-4179 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114379 | - |
dc.description.abstract | The role played by the biologically active CART 55–102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55–102 tested (0.1, 0.4, 1.0 or 2.5 μg/0.5 μl/side) produced effects on locomotion during a two-h test. However, when co-injected with AMPH (2.5 μg/0.5 μl/side) into the NAcc, moderately high (2.5 μg/side) and middle to high (0.4–2.5 μg/side) doses of CART 55–102 significantly attenuated the effects of AMPH on locomotion and rearing, respectively. These results indicate that CART peptides can exert an antagonistic effect on the generation of locomotion by AMPH in the NAcc. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 369~373 | - |
dc.relation.isPartOf | NEUROPEPTIDES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amphetamine/administration & dosage | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Central Nervous System Stimulants/administration & dosage | - |
dc.subject.MESH | Locomotion/drug effects* | - |
dc.subject.MESH | Locomotion/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microinjections | - |
dc.subject.MESH | Nerve Tissue Proteins | - |
dc.subject.MESH | Nucleus Accumbens/drug effects* | - |
dc.subject.MESH | Nucleus Accumbens/physiology | - |
dc.subject.MESH | Peptide Fragments/pharmacology | - |
dc.subject.MESH | Peptide Fragments/physiology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Time Factors | - |
dc.title | Microinjection of CART peptide 55–102 into the nucleus accumbens blocks amphetamine-induced locomotion | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | J.-H. Kim | - |
dc.contributor.googleauthor | E. Creekmore | - |
dc.contributor.googleauthor | P. Vezina | - |
dc.identifier.doi | 10.1016/j.npep.2003.10.001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00908 | - |
dc.relation.journalcode | J02351 | - |
dc.identifier.eissn | 1532-2785 | - |
dc.identifier.pmid | 14698680 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0143417903001070 | - |
dc.subject.keyword | CART | - |
dc.subject.keyword | Amphetamine | - |
dc.subject.keyword | Locomotion | - |
dc.subject.keyword | Nucleus accumbens | - |
dc.contributor.alternativeName | Kim, Jeong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 369 | - |
dc.citation.endPage | 373 | - |
dc.identifier.bibliographicCitation | NEUROPEPTIDES, Vol.37(6) : 369-373, 2003 | - |
dc.identifier.rimsid | 47264 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.