Cited 98 times in
TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-κB through TNF receptor-associated factors
DC Field | Value | Language |
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dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2015-07-15T17:09:39Z | - |
dc.date.available | 2015-07-15T17:09:39Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114349 | - |
dc.description.abstract | TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family that induces angiogenesis in vivo. The TWEAK receptor (TweakR) is a recently identified member of the TNF receptor (TNFR) superfamily and is expressed on smooth muscle cells (SMCs) and endothelial cells (ECs). In this report we identify the TNF receptor-associated factor (TRAF) family of signal transducers as important components of TweakR-mediated NF-κB activation. Coimmunoprecipitation experiments suggested potential interactions between the cytoplasmic tail of TweakR with TRAFs 1, 2, 3, and 5. Dominant negative forms of TRAF2 and TRAF5 substantially inhibited TweakR-mediated NF-κB activation, suggesting a role of TRAFs in regulating smooth muscle and endothelial cell function. Using alanine-scanning analysis, we defined a TRAF-binding motif, PIEET, in TweakR that mediates TRAF binding and NF-κB activation. Furthermore, TweakR mutations within the TRAF-binding motif abolished TweakR-stimulated SMC migration, revealing a role for TRAFs in TweakR-induced activation events. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 789~796 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Tweak receptor | - |
dc.subject.MESH | TRAFs | - |
dc.subject.MESH | Signal transducers | - |
dc.subject.MESH | NF-κB | - |
dc.subject.MESH | Smooth muscle cells | - |
dc.subject.MESH | Cell migration | - |
dc.title | TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-κB through TNF receptor-associated factors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Songyi Han | - |
dc.contributor.googleauthor | Kwiyeom Yoon | - |
dc.contributor.googleauthor | Soo Young Lee | - |
dc.contributor.googleauthor | Kichul Hwang | - |
dc.contributor.googleauthor | Na Kyung Lee | - |
dc.contributor.googleauthor | Hyunduk Jang | - |
dc.contributor.googleauthor | Kyunghee Kim | - |
dc.contributor.googleauthor | Kyunghye Lee | - |
dc.identifier.doi | 10.1016/S0006-291X(03)00852-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 10.1016/S0006-291X(03)00852-0 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X03008520 | - |
dc.subject.keyword | Tweak receptor | - |
dc.subject.keyword | TRAFs | - |
dc.subject.keyword | Signal transducers | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Smooth muscle cells | - |
dc.subject.keyword | Cell migration | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 305 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 789 | - |
dc.citation.endPage | 796 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.305(4) : 789-796, 2003 | - |
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