Cited 0 times in
심혈관질환 관련 위험요인 및 SNP 특이 유전율 연구 : Regression of Offspring on Mid-Parent(ROMP) 방법 적용
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2015-07-15T17:08:08Z | - |
dc.date.available | 2015-07-15T17:08:08Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1225-3596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114297 | - |
dc.description.abstract | Purpose : The objective of this study was to estimate the heritability attributable to single-locus effects with a regression of offspring on mid-parent(ROMP) method for cardiovascular risk factors. Methods : The regression of offspring on mid-parent is determined with and without the inclusion of a single-locus effect, and the difference between the slopes of these two regression is an estimate of the heritability attributable to the single-locus effect. The study population included 1.550 family members of 295 patients, derived from cardiovascular genome center. The risk factors considered were total serum cholesterol, triglyceride, LDL cholesterol, apoAI and apoB. Heritability was estimated from the slope of the linear regression of offspring on mid-parents. Results : Estimated heritability was 35 to 46% for total cholesterol with 6.2% attributable to polymorphism S128R. For triglyceride, the estimated heritability was 47.6% with 2% attributable to polymorphism G-217A. The heritability was 36-46% for LDL-cholesterol. For LDL cholesterol, S128R specific effect was 8.7%. Estimated heritability was 62.2% for apoAI with 3.2% attributable to polymorphism G-217A and 58 to 75% for apoB with 5.4% attributable to polymorphism S128R. Conclusions : These traits were significantly associated with polymorphism S128R. These results highlight the importance of considering genetic factors in studies of cardiovascular risk factors. Unlike traditional population-based tests of association, ROMP appears to be robust with respect to population stratification. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean Journal of Epidemiology | - |
dc.publisher | Korean Journal of Epidemiology | - |
dc.relation.isPartOf | Korean Journal of Epidemiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Quantitative traits | - |
dc.subject.MESH | Heritablility | - |
dc.subject.MESH | Cardiovascular | - |
dc.subject.MESH | Risk factor | - |
dc.title | 심혈관질환 관련 위험요인 및 SNP 특이 유전율 연구 : Regression of Offspring on Mid-Parent(ROMP) 방법 적용 | - |
dc.title.alternative | Estimation of heritability attributable to single-locus effects with a regression of offspring on mid-parent (ROMP) method for cardiovascular risk factors. | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | 지선하 | - |
dc.contributor.googleauthor | 박정용 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.contributor.googleauthor | 조은영 | - |
dc.contributor.googleauthor | 김민지 | - |
dc.contributor.googleauthor | 윤지은 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J02004 | - |
dc.subject.keyword | Quantitative traits | - |
dc.subject.keyword | Heritablility | - |
dc.subject.keyword | Cardiovascular | - |
dc.subject.keyword | Risk factor | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 31 | - |
dc.identifier.bibliographicCitation | Korean Journal of Epidemiology, Vol.25(1) : 24-31, 2003 | - |
dc.identifier.rimsid | 41898 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.