Cited 11 times in
A comprehensive karyotypic analysis on Korean hepatocellular carcinoma cell lines by cross-species color banding and comparative genomic hybridization
DC Field | Value | Language |
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dc.contributor.author | 오정탁 | - |
dc.date.accessioned | 2015-07-15T17:04:01Z | - |
dc.date.available | 2015-07-15T17:04:01Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0929-1903 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114159 | - |
dc.description.abstract | Chromosomal aberrations were investigated in hepatitis B virus integrated into the hepatocellular carcinoma (HCC) cell lines SNU-368, SNU-449, SNU-398, SNU-182, and SNU-475 using Giemsa-banding, cross species color banding, and comparative genomic hybridization (CGH). The origins of the marker chromosomes were confirmed by fluorescence in situ hybridization with constructed chromosome painting probes. Each cell line had unique modal karyotypic characteristics and showed variable numbers of numerical and structural clonal cytogenetic aberrations. The gains were commonly detected on chromosome 1, and chromosome regions 6p, 7q, 8q, 10p, 17q, and 20; the losses were often found on 4q21∼qter, 13, 18q21∼qter, and Y. In particular, the breakpoints on 1p36, 1p13∼q21, 2p13∼q11, 6q10∼q11, 7q11, 7q22, 14q10, 16q10∼q13, 17q21, 18q21, and 19p11∼q11 were involved frequently at the multiple rearranged lesions. CGH analysis further confirmed the cytogenetic data, and the nonrandom rearrangements data suggested the candidate regions for the genes to be isolated which were related to HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 128~137 | - |
dc.relation.isPartOf | CANCER GENE THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics* | - |
dc.subject.MESH | Chromosome Aberrations* | - |
dc.subject.MESH | Chromosome Banding* | - |
dc.subject.MESH | Color | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Karyotyping | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Nucleic Acid Hybridization | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | A comprehensive karyotypic analysis on Korean hepatocellular carcinoma cell lines by cross-species color banding and comparative genomic hybridization | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Hye-Jin Hwang | - |
dc.contributor.googleauthor | Gi-Jin Kim | - |
dc.contributor.googleauthor | Sun-Hwa Park | - |
dc.contributor.googleauthor | Yong-Hyuck Chun | - |
dc.contributor.googleauthor | Jung-Tak Oh | - |
dc.contributor.googleauthor | Gi-Bong Lee | - |
dc.identifier.doi | 10.1016/S0165-4608(02)00671-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02397 | - |
dc.relation.journalcode | J00442 | - |
dc.identifier.eissn | 1476-5500 | - |
dc.identifier.pmid | 12606130 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460802006714 | - |
dc.subject.keyword | 12606130 | - |
dc.contributor.alternativeName | Oh, Jung Tak | - |
dc.contributor.affiliatedAuthor | Oh, Jung Tak | - |
dc.contributor.affiliatedAuthor | 오정탁 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 141 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 128 | - |
dc.citation.endPage | 137 | - |
dc.identifier.bibliographicCitation | CANCER GENE THERAPY, Vol.141(2) : 128-137, 2003 | - |
dc.identifier.rimsid | 52036 | - |
dc.type.rims | ART | - |
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