Cited 130 times in
Activation Systems for Latent Matrix Metalloproteinase-2 Are Upregulated Immediately After Focal Cerebral Ischemia
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2015-07-15T17:03:37Z | - |
dc.date.available | 2015-07-15T17:03:37Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114145 | - |
dc.description.abstract | During focal cerebral ischemia, matrix metalloproteinase-2 (MMP-2) can contribute to the loss of microvessel integrity within ischemic regions by degrading the basal lamina. MMP-2 is secreted in latent form (pro-MMP-2), but the activation of pro-MMP-2 in the ischemic territory has not been shown. Immunohistochemical and in situ hybridization studies of the expression of the direct activators of MMP-2, MT1-MMP and MT3-MMP, and the indirect activation system tissue plasminogen activator, urokinase (u-PA), its receptor (u-PAR), and its inhibitor PAI-1 after middle cerebral artery occlusion/reperfusion were undertaken in basal ganglia samples from 26 adolescent male baboons. The expressions of all three MMPs, u-PA, u-PAR, and PA1-1, but not tissue plasminogen activator, were increased from 1 hour after middle cerebral artery occlusion in the ischemic core. mRNA transcripts confirmed the increases in latent MMP-2, u-PA, u-PAR, and PAI-1 antigen very early after middle cerebral artery occlusion. The expression patterns are consistent with secretion of pro-MMP-2 and its activators in the ischemic core, perhaps from separate cell compartments. The rapid and coordinate appearance of pro-MMP-2 and its activation apparatus suggest that in the primate striatum this protease may participate in matrix injury during focal cerebral ischemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1408~1419 | - |
dc.relation.isPartOf | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Activation Systems for Latent Matrix Metalloproteinase-2 Are Upregulated Immediately After Focal Cerebral Ischemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Dae-Il Chang | - |
dc.contributor.googleauthor | Naohisa Hosomi | - |
dc.contributor.googleauthor | Gregory J del Zoppo | - |
dc.contributor.googleauthor | Andrew P Mazarparallel | - |
dc.contributor.googleauthor | Takeo Abumiya | - |
dc.contributor.googleauthor | Ji-Hoe Heo | - |
dc.contributor.googleauthor | Jacinta Lucero | - |
dc.identifier.doi | 10.1097/01.WCB.0000091765.61714.30 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J01306 | - |
dc.identifier.eissn | 1559-7016 | - |
dc.identifier.pmid | 10.1097/01.WCB.0000091765.61714.30 | - |
dc.identifier.url | http://www.nature.com/jcbfm/journal/v23/n12/abs/9591490a.html | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1408 | - |
dc.citation.endPage | 1419 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol.23(12) : 1408-1419, 2003 | - |
dc.identifier.rimsid | 52024 | - |
dc.type.rims | ART | - |
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