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Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci
DC Field | Value | Language |
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dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2015-07-15T17:02:44Z | - |
dc.date.available | 2015-07-15T17:02:44Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114115 | - |
dc.description.abstract | We determined the macrolide resistance phenotypes of 241 clinical isolates of erythromycin-resistant enterococci (MICs, ≥1 μg/ml), including 147 Enterococcus faecalis strains and 94 Enterococcus faecium strains, collected from a hospital in Seoul, Korea, between 1999 and 2000. By the erythromycin (40 μg)-josamycin (100 μg) double-disk test, 93 strains were assigned to the constitutive macrolide, lincosamide, and streptogramin B (MLSB) resistance (cMLSB) phenotype, and the remaining 148 strains were assigned to the inducible MLSB resistance (iMLSB) phenotype. Of the strains with the iMLSB phenotype, 36 exhibited a reversibly inducible MLSB (riMLSB) phenotype, i.e., blunting of the erythromycin zone of inhibition, which indicates that the 16-membered-ring macrolide josamycin is a more effective inducer than the 14-membered-ring macrolide erythromycin. Sequence analysis of the regulatory regions of the erm(B) genes from all of the strains exhibiting the riMLSB phenotype revealed not only erm(Bv) [where v represents variant; previously erm(AMR)] (n = 13), as reported previously, but also three kinds of erm(B) variants, which were designated erm(Bv1) (n = 17), erm(Bv2) (n = 3), and erm(Bv3) (n = 3), respectively. In lacZ reporter gene assays of these variants, the 16-membered-ring macrolide tylosin had stronger inducibility than erythromycin at ≥0.1 μg/ml. These findings highlight the versatility of erm(B) in induction specificity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3415~3420 | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology* | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Drug Resistance, Bacterial | - |
dc.subject.MESH | Enterococcus faecalis/drug effects* | - |
dc.subject.MESH | Enterococcus faecalis/growth & development | - |
dc.subject.MESH | Enterococcus faecium/drug effects* | - |
dc.subject.MESH | Enterococcus faecium/growth & development | - |
dc.subject.MESH | Lac Operon/genetics | - |
dc.subject.MESH | Lincosamides | - |
dc.subject.MESH | Macrolides/pharmacology* | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Plasmids/genetics | - |
dc.subject.MESH | Streptogramin B/pharmacology* | - |
dc.subject.MESH | beta-Galactosidase/biosynthesis | - |
dc.title | Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yu-Hong Min | - |
dc.contributor.googleauthor | Jae-Hee Jeong | - |
dc.contributor.googleauthor | Eung-Chil Choi | - |
dc.contributor.googleauthor | Jin-Hwan Kwak | - |
dc.contributor.googleauthor | Mi-Ja Shim | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Hee-Jeong Yun | - |
dc.contributor.googleauthor | Yun-Jeong Choi | - |
dc.identifier.doi | 10.1128/AAC.47.11.3415-3420.2003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J00189 | - |
dc.identifier.eissn | 1098-6596 | - |
dc.identifier.pmid | 14576096 | - |
dc.subject.keyword | 14576096 | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3415 | - |
dc.citation.endPage | 3420 | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.47(11) : 3415-3420, 2003 | - |
dc.identifier.rimsid | 55727 | - |
dc.type.rims | ART | - |
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