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Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice
DC Field | Value | Language |
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dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-07-15T17:02:10Z | - |
dc.date.available | 2015-07-15T17:02:10Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114096 | - |
dc.description.abstract | Treatment with a neutralizing anti-transforming growth factor-beta (TGF-beta) antibody can prevent the development of diabetic nephropathy in the db/db mouse, a model of type 2 diabetes. However, it is unknown whether anti-TGF-beta therapy can reverse the histological lesions of diabetic glomerulopathy once they are established. Diabetic db/db mice and their non-diabetic db/m littermates were allowed to grow until 16 weeks of age, by which time the db/db mice had developed glomerular basement membrane (GBM) thickening and mesangial matrix expansion. The mice were then treated with an irrelevant control IgG or a panselective, neutralizing anti-TGF-beta antibody for eight more weeks. Compared with control db/m mice, the db/db mice treated with IgG had developed increased GBM width (16.64+/-0.80 nm vs. 21.55+/-0.78 nm, P<0.05) and increased mesangial matrix fraction (4.01+/-0.81% of total glomerular area vs. 9.55+/-1.04%, P<0.05). However, the db/db mice treated with anti-TGF-beta antibody showed amelioration of GBM thickening (18.40+/-0.72 nm, P<0.05 vs. db/db-IgG) and mesangial matrix accumulation (6.32+/-1.79%, P<0.05 vs. db/db-IgG). Our results demonstrate that inhibiting renal TGF-beta activity can partially reverse the GBM thickening and mesangial matrix expansion in this mouse model of type 2 diabetes. Anti-TGF-beta regimens would be useful in the treatment of diabetic nephropathy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 16~22 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Basement Membrane/pathology | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Diabetic Nephropathies/genetics | - |
dc.subject.MESH | Diabetic Nephropathies/pathology | - |
dc.subject.MESH | Diabetic Nephropathies/prevention & control | - |
dc.subject.MESH | Diabetic Nephropathies/therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Mesangium/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin G/administration & dosage | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Mutant Strains | - |
dc.subject.MESH | Neutralization Tests | - |
dc.subject.MESH | Transforming Growth Factor beta/antagonists & inhibitors* | - |
dc.subject.MESH | Transforming Growth Factor beta/physiology | - |
dc.title | Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sheldon Chen | - |
dc.contributor.googleauthor | M Carmen Iglesias-de la Cruz | - |
dc.contributor.googleauthor | Fuad N Ziyadeh | - |
dc.contributor.googleauthor | Motohide Isono | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.contributor.googleauthor | Belinda Jim | - |
dc.identifier.doi | 10.1016/S0006-291X(02)02708-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 12480514 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X02027080 | - |
dc.subject.keyword | Glomerular basement membrane thickening | - |
dc.subject.keyword | Mesangial matrix expansion | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.subject.keyword | Reversal | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 300 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 16 | - |
dc.citation.endPage | 22 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.300(1) : 16-22, 2003 | - |
dc.identifier.rimsid | 55712 | - |
dc.type.rims | ART | - |
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