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New approaches to functional process discovery in HPV 16-associated cervical cancer cells by gene ontology
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.date.accessioned | 2015-07-15T17:01:44Z | - |
dc.date.available | 2015-07-15T17:01:44Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114081 | - |
dc.description.abstract | Purpose: This study utilized both mRNA differential display and the Gene Ontology (GO) analysis to characterize the multiple interactions of a number of genes with gene expression profiles involved in the HPV-16- induced cervical carcinogenesis. Materials and Methods: mRNA differential displays, with HPV-16 positive cervical cancer cell line (SiHa), and normal human keratinocyte cell line (HaCaT) as a control, were used. Each human gene has several biological functions in the Gene Ontology; therefore, several functions of each gene were chosen to establish a powerful cervical carcinogenesis pathway. The specific functions assigned to these genes were then correlated with the gene expression patterns. Results: The results showed that 157 genes were up- or down-regulated at least 2-fold and organized into reciprocally dependent sub-function sets, depending on their cervical cancer pathway, suggesting the potentially significant genes of unknown function affected by the HPV-16-derived pathway. The GO analysis suggested that the cervical cancer cells underwent repression of the cancer-specific cell adhesive properties. Also, genes belonging to DNA metabolism, such as DNA repair and replication, were strongly down-regulated, whereas significant increases were shown in the protein degradation and synthesis. Conclusion: The GO analysis can overcome the complexity of the gene expression profile of the HPV-16- associated pathway, identify several cancer-specific cellular processes and genes of unknown function. It could also become a major competing platform for the genome- wide characterization of carcinogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cervix neoplasia | - |
dc.subject.MESH | mRNA differential display | - |
dc.subject.MESH | Gene ontology | - |
dc.title | New approaches to functional process discovery in HPV 16-associated cervical cancer cells by gene ontology | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Yong-Wan Kim | - |
dc.contributor.googleauthor | Min-Je Suh | - |
dc.contributor.googleauthor | Woong Shick Ahn | - |
dc.contributor.googleauthor | Chong Kook Kim | - |
dc.contributor.googleauthor | Sung Eun Namkoong | - |
dc.contributor.googleauthor | Joon Mo Lee | - |
dc.contributor.googleauthor | Duck Young Ro | - |
dc.contributor.googleauthor | Jae Hoon Kim | - |
dc.contributor.googleauthor | Soo Young Hur | - |
dc.contributor.googleauthor | Joo Hee Yoon | - |
dc.contributor.googleauthor | Su Mi Bae | - |
dc.contributor.googleauthor | Jin-Sik Bae | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.subject.keyword | Cervix neoplasia | - |
dc.subject.keyword | mRNA differential display | - |
dc.subject.keyword | Gene ontology | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 304 | - |
dc.citation.endPage | 313 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.35(4) : 304-313, 2003 | - |
dc.identifier.rimsid | 55702 | - |
dc.type.rims | ART | - |
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