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Detection of germinal center B-cell lymphoma in archival specimens: critical evaluation of Bcl-6 protein expression in diffuse large B-cell lymphoma of the tonsil
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2015-07-15T16:59:41Z | - |
dc.date.available | 2015-07-15T16:59:41Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114013 | - |
dc.description.abstract | Expression of Bcl-6 and CD10, markers for the tumor of the germinal center (GC) B-cell derivation, has been studied in primary diffuse large B-cell lymphomas (DLBCLs) of the lymph node, gastrointestinal tract, and mediastinum. In these studies, the coexpression rate of CD10 and Bcl-6 was relatively constant at 30%∼40%, but the frequency of Bcl-6+ tumors varied from 55% to 100%, raising doubts about the usefulness of Bcl-6 expression in identifying the tumor of GC B-cell derivation. Because the expression of Bcl-6 in tumors of non-GC B-cell origin has recently been reported, we critically evaluated the expression of Bcl-6 and CD10 in primary DLBCLs of the tonsil, a relatively common tumor in Japan and Korea. The cases (n = 51) represented a consecutive series for any recent 2-year period at several teaching hospitals in Korea and Japan. Formalin-fixed, paraffin-embedded specimens were used for immunostaining. Staining for Bcl-6 and CD10 was positive in 44 (86%) and 22 cases (45%), respectively. However, among those positive for Bcl-6 (>10% Bcl-6+ tumor cells), 2 basic patterns were recognized: uniform and nonuniform. The uniform pattern was characterized by a dense population (>75%) and a consistent density in any given area, resembling the staining pattern observed in GC or follicular lymphoma (FL) (the “GC/FL” pattern). In contrast, the nonuniform pattern exhibited a varying density from area to area, as well as a less-dense population (<75%). The uniform pattern was observed in 26 cases (51%). All but 1 (95%) of the CD10+ tumors coexpressed Bcl-6, with most (82%) displaying the uniform pattern. We conclude that tumors showing a uniform pattern of Bcl-6 expression should be distinguished from those showing a nonuniform pattern, because the former most likely represent tumors of GC B-cell derivation and the latter most likely represent tumors of non-GC derivation. GC B-cell lymphoma thus defined accounted for 51% of tonsillar DLBCL, a proportion comparable to that of the nodal DLBCL. CD10 expression correlated with the “GC/FL” pattern, but appeared to be not essential for the identification of GC B-cell lymphoma. This study suggests that a significant proportion of tonsillar DLBCLs in Asia is of GC B-cell origin rather than of mucosa-associated lymphoid tissue origin. This finding may have significance for clinical management of these lymphomas. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 610~616 | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | tonsillar lymphoma | - |
dc.subject.MESH | germinal center | - |
dc.subject.MESH | B-cell lymphoma | - |
dc.subject.MESH | diffuse large B-cell lymphoma | - |
dc.subject.MESH | Bcl-6 expression | - |
dc.subject.MESH | CD10 expression | - |
dc.title | Detection of germinal center B-cell lymphoma in archival specimens: critical evaluation of Bcl-6 protein expression in diffuse large B-cell lymphoma of the tonsil | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Howe J. Ree | - |
dc.contributor.googleauthor | Koichi Ohsima | - |
dc.contributor.googleauthor | Shigeo Mori | - |
dc.contributor.googleauthor | Masahiro Kikuchi | - |
dc.contributor.googleauthor | Jong Chul Rhee | - |
dc.contributor.googleauthor | Yoon-La Choi | - |
dc.contributor.googleauthor | Eun Yoon Cho | - |
dc.contributor.googleauthor | Mi Seon Kwon | - |
dc.contributor.googleauthor | Yong-Hye Ko | - |
dc.contributor.googleauthor | Seung-Sook Lee | - |
dc.contributor.googleauthor | Joor Yung Huh | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Chul Woo Kim | - |
dc.contributor.googleauthor | Kengo Takeuchi | - |
dc.contributor.googleauthor | Katsuyuki Aozasa | - |
dc.identifier.doi | 10.1016/S0046-8177(03)00086-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 10.1016/S0046-8177(03)00086-8 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0046817703000868 | - |
dc.subject.keyword | tonsillar lymphoma | - |
dc.subject.keyword | germinal center | - |
dc.subject.keyword | B-cell lymphoma | - |
dc.subject.keyword | diffuse large B-cell lymphoma | - |
dc.subject.keyword | Bcl-6 expression | - |
dc.subject.keyword | CD10 expression | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 610 | - |
dc.citation.endPage | 616 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.34(6) : 610-616, 2003 | - |
dc.identifier.rimsid | 55648 | - |
dc.type.rims | ART | - |
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