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Enolase-α Is Frequently Down-Regulated in Non-Small Cell Lung Cancer and Predicts Aggressive Biological Behavior
DC Field | Value | Language |
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dc.contributor.author | 장윤수 | - |
dc.date.accessioned | 2015-07-15T16:58:48Z | - |
dc.date.available | 2015-07-15T16:58:48Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113983 | - |
dc.description.abstract | PURPOSE: Enolase-alpha is a cytoplasmic glycolytic enzyme important in the formation of phosphoenolpyruvate. Enolase-alpha and c-myc binding protein (MBP-1) originate from a single gene through alternative use of translational starting sites. Both enolase-alpha and MBP-1 can bind to the P2 element in the c-myc promoter and compete with TATA-box binding protein (TBP) to suppress transcription of c-myc. EXPERIMENTAL DESIGN: To determine a potential role of enolase-alpha in vivo, we analyzed enolase-alpha expression in non-small cell lung cancer (NSCLC) tissues from 46 patients by Western blotting and immunohistochemical analysis. RESULTS: Twelve (26%) of the 46 tumors showed a significantly reduced enolase-alpha expression. Although no statistically significant association was observed between the down-regulation of enolase-alpha and pathological stage, tumor histology, or differentiation, the patients whose tumors showed reduced enolase-alpha expression had a significantly poorer overall survival compared with those without down-regulation of this molecule (P = 0.0398). CONCLUSIONS: Our results indicate down-regulation of enolase-alpha is common in NSCLC and may play an important role in lung tumorigenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CLINICAL CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/enzymology* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/mortality | - |
dc.subject.MESH | DNA-Binding Proteins/biosynthesis* | - |
dc.subject.MESH | Down-Regulation* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lung Neoplasms/enzymology* | - |
dc.subject.MESH | Lung Neoplasms/metabolism | - |
dc.subject.MESH | Lung Neoplasms/mortality | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphopyruvate Hydratase/biosynthesis* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tumor Suppressor Proteins/biosynthesis* | - |
dc.title | Enolase-α Is Frequently Down-Regulated in Non-Small Cell Lung Cancer and Predicts Aggressive Biological Behavior | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yoon Soo Chang | - |
dc.contributor.googleauthor | Weiguo Wu | - |
dc.contributor.googleauthor | Li Mao | - |
dc.contributor.googleauthor | Waun Ki Hong | - |
dc.contributor.googleauthor | Garrett Walsh | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03456 | - |
dc.relation.journalcode | J00564 | - |
dc.identifier.pmid | 14506152 | - |
dc.subject.keyword | 14506152 | - |
dc.contributor.alternativeName | Chang, Yoon Soo | - |
dc.contributor.affiliatedAuthor | Chang, Yoon Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 10 Pt 1 | - |
dc.citation.startPage | 3641 | - |
dc.citation.endPage | 3644 | - |
dc.identifier.bibliographicCitation | CLINICAL CANCER RESEARCH, Vol.9(10 Pt 1) : 3641-3644, 2003 | - |
dc.identifier.rimsid | 54035 | - |
dc.type.rims | ART | - |
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