Cited 0 times in
한국인 급성 심근경색증 환자에서 Tenecteplase(TNK-tPA)와 Alteplase(rt-PA)의 효과 비교(무작위, 다기관, 관상동맥 조영술을 이용한 임상 시험)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-07-15T16:56:27Z | - |
dc.date.available | 2015-07-15T16:56:27Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113904 | - |
dc.description.abstract | Background and Objectives:This is a comparative, randomized, multi-centered, angiographic trial for the comparison of TNK-tPA with rt-PA, in Korean patients with an acute myocardial infarction (AMI). Subjects and Methods:Fifty four patients that were eligible for thrombolysis, diagnosed with an AMI, were randomized into two groups:TNK-tPA (single bolus injection, 25-50 mg weight adjusted;n=25) or rt-PA (accelerated intravenous infusion, up to 100 mg;n=29) at the emergency room. The primary endpoint was the percentage of patients with a TIMI (Thrombolysis In Myocardial Infarction) III flow 90 min following the administration of the study drug. The secondary endpoints were an infarct-related artery patency at 90 min, the percentage of patients with ST segment resolution at 60 and 180 min, and at 30 days mortality. Results:The baseline demographic data, including age, sex and body weight, and a medical history of prior myocardial infarction and risk factors were no different between the TNK-tPA and rt-PA groups. The pain-to-needle and door-to-needle times were also no different. The ST segment resolution was no different between the two groups. A TIMI grade 3, on a coronary angiogram, 90 min following the drug administration, was observed in 19 (76.0%) of the TNK-tPA and 17 (58.6%) of the rt-PA (p=0.24) patients. However, a TIMI grade more than 2 was higher in the TNK-tPA (100%;25/25) than in rt-PA group (72.4%;21/29)(p=0.0052). The in-hospital adverse events, and clinical outcomes at 30 days, were no different between the two groups. Conclusion:TNK-tPA is more convenient, and may be a preferred thrombolytic agent, for the revascularization of an AMI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Coronary disease;Myocardial infarction;Thrombolysis, therapeutic;Myocardial revascularization;Survival | - |
dc.title | 한국인 급성 심근경색증 환자에서 Tenecteplase(TNK-tPA)와 Alteplase(rt-PA)의 효과 비교(무작위, 다기관, 관상동맥 조영술을 이용한 임상 시험) | - |
dc.title.alternative | A Comparison of Tenecteplase(TNK-tPA) and Alteplase(rt-PA) in Korean Patients with Acute Myocardial Infarction(A Randomized, Multi-Centered Coronary Angiographic Trial) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 정명호 | - |
dc.contributor.googleauthor | 김원 | - |
dc.contributor.googleauthor | 최경훈 | - |
dc.contributor.googleauthor | 윤정한 | - |
dc.contributor.googleauthor | 유병수 | - |
dc.contributor.googleauthor | 조승연 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.contributor.googleauthor | 최동훈 | - |
dc.contributor.googleauthor | 탁승제 | - |
dc.contributor.googleauthor | 최소연 | - |
dc.contributor.googleauthor | 박승정 | - |
dc.contributor.googleauthor | 박성욱 | - |
dc.contributor.googleauthor | 홍명기 | - |
dc.contributor.googleauthor | 오병희 | - |
dc.contributor.googleauthor | 채인호 | - |
dc.contributor.googleauthor | 배종화 | - |
dc.contributor.googleauthor | 강흥선 | - |
dc.contributor.googleauthor | 김무현 | - |
dc.contributor.googleauthor | 차광수 | - |
dc.contributor.googleauthor | 김권배 | - |
dc.contributor.googleauthor | 허승호 | - |
dc.contributor.googleauthor | 한성욱 | - |
dc.contributor.googleauthor | 강정채 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01953 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.subject.keyword | Coronary disease;Myocardial infarction;Thrombolysis, therapeutic;Myocardial revascularization;Survival | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 362 | - |
dc.citation.endPage | 373 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.33(5) : 362-373, 2003 | - |
dc.identifier.rimsid | 41478 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.