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진균혈증의 진단에 있어서 혈청 (1→3)-β-D-glucan 측정의 유용성
DC Field | Value | Language |
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dc.contributor.author | 김준명 | - |
dc.contributor.author | 송영구 | - |
dc.date.accessioned | 2015-07-15T16:55:59Z | - |
dc.date.available | 2015-07-15T16:55:59Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1598-8112 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113888 | - |
dc.description.abstract | Background:Early recognition of fungemia is essential for successful treatment. However, methods to culture fungus specimen taken from fungemia patients are difficult and time consuming. To assess the clincal usefulness of β-D-glucan in the detection of fungemia, we compared serum (1→3)-β-D-glucan concentrations in fungemia, bacteremia, and healthy persons. Methods:From August 2001 to October 2002, serum (1→3)-β-D-glucan concentrations were measured by turbidometric assay in 16 fungemia patients, 13 bacteremia patients and 18 healthy persons. Differences in (1→3)-β-D-glucan concentrations between fungemia patients and other groups were compared by t-test. Results:Fungemia patients were composed of 10 male and 6 female patients, and mean age was 52.9±16.2 years. The cut-off value for a positive result was 11 pg/mL. thirteen out of 16 fungemia patients had concentrations above the cul-off value (range:11.5-863 pg/mL, sensitivity:81.3%, specificity:100%), and mean concentration in fungemia was 217.8±273.8 pg/mL. Mean concentration in bacteremia was 0.1±0.3 pg/mL, and all the patients with bacteremia had the concentrations below the cut-off value. Mean concentration in the healthy persons was 0 pg/mL and all healthy persons had concentration below the cut-off value. The concentration in fungemia was statistically significantly higher than those of the other two groups(p-value: respectively 0.006, 0.006) Conclusion:We concluded that serum (1→3)-β-D-glucan is useful for the diagnosis of fungemia. Further study on the usefullness of serum (1→3)-β-D-glucan for early detection of fungemia and therapeutic monitoring is warranted. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | INFECTION AND CHEMOTHERAPY (감염과 화학요법) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | (1→3)-β-D-glucan | - |
dc.subject.MESH | Fungemia | - |
dc.subject.MESH | Fungus | - |
dc.subject.MESH | Fungal infection | - |
dc.title | 진균혈증의 진단에 있어서 혈청 (1→3)-β-D-glucan 측정의 유용성 | - |
dc.title.alternative | Clinical Usefulness of Serum (1→3)-β-D-glucan Measurement in the Diagnosis of Fungemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 최석훈 | - |
dc.contributor.googleauthor | 한상훈 | - |
dc.contributor.googleauthor | 김준명 | - |
dc.contributor.googleauthor | 송영구 | - |
dc.contributor.googleauthor | 장경희 | - |
dc.contributor.googleauthor | 이꽃실 | - |
dc.contributor.googleauthor | 김윤재 | - |
dc.contributor.googleauthor | 김희만 | - |
dc.contributor.googleauthor | 조병철 | - |
dc.contributor.googleauthor | 박윤선 | - |
dc.contributor.googleauthor | 진범식 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A02037 | - |
dc.relation.journalcode | J01054 | - |
dc.subject.keyword | (1→3)-β-D-glucan | - |
dc.subject.keyword | Fungemia | - |
dc.subject.keyword | Fungus | - |
dc.subject.keyword | Fungal infection | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.35(4) : 205-209, 2003 | - |
dc.identifier.rimsid | 41463 | - |
dc.type.rims | ART | - |
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