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Oxysterols induce apoptosis and accumulation of cell cycle at G2/M phase in the human monocytic THP-1 cell line

Authors
 Hee-Kyoung Lim  ;  Hee-Kyoung Kang  ;  Jin-Won Hyun  ;  Myung-Hee Chung  ;  Yun-Sil Lee  ;  Jae-Hwa Lee  ;  Moonjae Cho  ;  Youn-Woo Kim  ;  Bum-Joon Kim  ;  Eun-Sook Yoo 
Citation
 LIFE SCIENCES, Vol.72(12) : 1389-1399, 2003 
Journal Title
LIFE SCIENCES
ISSN
 0024-3205 
Issue Date
2003
MeSH
Apoptosis/drug effects* ; Blotting, Western ; DNA Fragmentation ; Flow Cytometry ; G2 Phase/drug effects* ; HL-60 Cells/pathology ; Humans ; Hydroxycholesterols/pharmacology* ; Leukemia/pathology ; Leukemia, Monocytic, Acute/pathology* ; Leukemia-Lymphoma, Adult T-Cell ; Mitosis/drug effects* ; Tumor Cells, Cultured
Keywords
Oxysterol ; Apoptosis ; Cell cycle ; Cytotoxicity
Abstract
The cytotoxic activity of oxysterols, 7β-hydroxycholesterol (7β-OHC) and 25-hydroxycholesterol (25-OHC), has been evaluated using various leukemia cell lines. Among the tested cell lines, both oxysterols showed the highest cytotoxicity to THP-1, human monocytic leukemia cell line. These oxysterols induced apoptosis through down-regulation of Bcl-2 expression and activation of caspases. Also, the oxysterols showed the accumulation at G2/M phase of cell cycle through down-regulation of cyclin B1 expression. Taken together, these results indicated that both 7β-OHC and 25-OHC inhibited the proliferation of THP-1 cells through apoptosis and cell cycle accumulation at G2/M phase.
Full Text
http://www.sciencedirect.com/science/article/pii/S0024320502023779
DOI
10.1016/S0024-3205(02)02377-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yun Sil(이윤실)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113837
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